Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-03-20
1999-03-30
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514312, 514314, 514332, 514335, 514339, 514340, 514341, 514343, 514397, 514398, 514399, 514414, 514415, 514438, 514444, 514471, 514473, 514867, A61K 3147, A61K 3144, A61K 31415, A61K 3140, A61K 31405, A61K 3138, A61K 3134
Patent
active
058890386
ABSTRACT:
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.
REFERENCES:
patent: 3655882 (1972-04-01), Wright et al.
patent: 3965112 (1976-06-01), White et al.
patent: 3984539 (1976-10-01), Khouw et al.
Rufo, P., et al., "The Antifungal Antibiotic, Clotimazole, Inhibits Cl.sup.- Secretion by Polarized . . . ", J. Clin. Invest., 1996, 98:9:2066-2075.
Rufo, P., et al., "Inhibition of K.sup.+ Transport and C.sup.- Secretion in T84 Cells by Clotrimazole (CLT)", J. General Physiology, 1995, 106:38a, Abstract.
Mentzer, D., et al., "Parenterale Ernahrung bei Gewichtsyerlust und chronischer Diarrhoe . . . " Aids-Forschung AIFO--5th German Aids Congress, 1994, 9:11:621 (#333) Abstract.
Peters, M., et al., "Die akute und chronische Diarrho", Med. Munatschr. Pharm., 1994, 17:12:358-366.
Brugnara C., et al., "Inhibition of CA2+-dependent K+ Transport and Cell Dehydration in Sickle . . . " J. Clin. Invest., 1993, 92:1:520-526.
Simon, D., et al., "Treatment Options for AIDS-Related Espohageal and Diarrheal Disorders", The American J. of Gastroenterology, 1992, 87:3:274-281.
Smith, P., et al., "Gastrointestinal Infections in AIDS", Annals of Internal Medicine, 1992, 116:1:63-77.
Tzipori et al., "The Journal of Infectious Diseases" 1995; 171:1069-71 by The University of Chicago.
Verdon et al., "The Journal of Infectious Diseases" 1995; 171:1069-71 by The University of Chicago.
White et al., "The Journal of Infectious Diseases" 1995; 171:1069-71 by The University of Chicago.
A. Plattenberg, A. Stoehr, H.J. Stellbrink, H. Albrecht, W. Meigel "A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea" Clin. Investig.(1993) 71:42-45.
Glendon D. Sinks, et al., "Effects of lasalocid infection and growth in young dairy calves" JAVMA, vol. No. 12, 1947-1951 (1992).
J.A. Rump et al., "Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum" Clin. Investig. (1992) 75:588-594.
R. Fayer "Activity of sulfadimethoxine against cryptosporidiosis in dairy calves" J. Parasitol., 78(3), 1992, pp. 534-537.
A.J. Roussel Jr., et al., "Effect of ketoprofen on Escherichia coli heat-stable enterotoxin-induced diarrhea in calves" Am. J. Vet. Res., vol. 54, No. 12, Dec. 1993,(2088-2090).
Hadya S. Nagesha, et al., "A variant serotype G3 rotavirus in piglets", Journal of Medical Virology 38:79-85 (1992).
H.W. Moon, DVM, PhD "Mechanisms in the pathogenesis of diarrhea: a review", Journal of the American Veterinary Medical Association, v. 172, 443-448 (1978).
Travis C. McGuire, DVM, PhD, et al., "Failure of colostral immunoglobulin transfer in calves dying from infectious disease", Journal Amer. Veterinary Medical Assoc. 169(7), 712-718 (1976).
Denis Archambault, DVM, PhD, et al., "Immune response of pregnant heifers and cows to bovine rotavirus inoculation and passive protection to rotavirus infection in newborn calves fed colostral antibodies or colostral lymphocytes", Am. J. Vet. Res., vol. 49, No. 7, 1084-1091 (1988).
Dale L. Haggard, DVM, MS, "Bovine enteric colibacillosis", Vet. Clinc. Of N. Am.: Food Animal Practice vol. 1, No. 3, 495-508 (1985).
F. Burki, et al., "Reduction of rotavirus-, coronavirus-and E. coli-associated calf-diarrheas in a large-size dairy herd by means of dam vaccination with a triple-vaccine", J. Vet. Med. B33,241-252 (1986).
"Bovine rota-coronavirus-Escherichia coli antibody (Bovine Origin) first defense", Immucell Corp. Product Instruction Sheet (1990).
D. Waltner-Toews, S.W., et al., "A field of evaluate the efficacy of a combined rotavirus-coronavirus/Escherichia coli vaccine in dairy cattle", Can. J. Comp. Med 49:1-9 (1985).
B. Kaijser, et al., "Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum Albumin", Infection and Immunity, v. 39 pp. 142-146 (1983).
I. Hajer, BVSC, PhD, et al., "Antigens of bovine coronavirus strain LY-138 and their diagnostic properties", Am. J. Vet. Res., vol. 39, pp. 441-444 (1978).
Harald Brussow, et al., "Cross-neutralizing antibodies induced by single serotype vaccination of cows with rotavirus", J. Gen. Virol. 69, 1647-1658 (1988).
R.C. Heel, R.N., et al., "Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections", Drugs 19:7-30 (1980).
W. Ritter, et al., "Pharmacokinetic fundamentals of vaginal treatment with clotrimazole", Chemotherapy 28 (Suppl. 1):37-42 (1982).
Wolfgang Ritter, PhD., "Pharmacokinetic fundamentals of vaginal treatment with clotrimazole", Am. J. Obstet. Gynecol. Aug. 1, 1985 (945-947).
B. Duhm et al., "The pharmacokinetics of clotrimazole .sup.14 C", Postgraduate Medical Journal 50 (Jul. Suppl.) 13-16 (1974).
Lucia DeFranceschi et al., "Treatment with oral clotrimazole blocks Ca.sup.2+ -activated K.sup.+ transport and reverses erythrocyte dehydration in transgenic SAD mice", J. Clin. Invest. vol. 93, 1670-1676 (1994).
Carlo Brugnara et al., "Inhibition of Ca.sup.2+ -dependent K.sup.+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives", J. Clin. Invest., vol. 92, 520-526 (1993).
Brugnara et al., "Ion channels and genetic diseases", Society of General Physiologists 48th Annual Symposium pp. 1-3 (1994).
Carlo Brugnara, et al., "Oral administration of clotrimazole and blockage of human erythrocyte Ca.sup.++ -Activated K.sup.+ Channel: the imidazole ring is not required for inhibitory activity.sup.1 ", JPET 273:266-272, (1995).
Mana Vajanaphanich, et al., "Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P.", Nature vol. 371, 711-714 (1994).
Carlo Brugnara, et al., "Therapy with oral clotrimazole induces inhibition of the gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease", J. Clin. Invest. vol. 97, No. 5, 1227-1234 (1996).
E. Lohrmann et al., "A new class of inhibitors of cAMP-mediated CI.sup.- secretion in rabbit colon, acting by the cAMP-Activated K.sup.+ conductance", Pflugers Arch--Eur. J. Physiol. 429:517-530 (1995).
Ilko G. Iliev, et al., "Potassium channels in epithelial cells", Cellular and Molecular Biology Research, vol. 39, No. 6, pp. 601-611, (1993).
Kiertisin Dharmsathaphorn, et al., "Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line", J. Clin. Invest., vol. 75, 462-471 (1985).
Alper Seth
Brugnara Carlo
Lencer Wayne I.
Children's Hospital
Jordan Kimberly
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