Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-07-03
1997-07-29
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
604 51, 604 52, 604 53, 536 235, 536 2351, 4353201, 4351721, 4351723, 935 9, 935 22, 935 32, 935 33, 935 34, 935 52, 935 57, 424 932, A01N 4740
Patent
active
056522258
ABSTRACT:
The present invention provides a method for the delivery of a nucleic acid to an arterial cell comprising contacting the cell with a hydrophilic polymer incorporating the nucleic acid. The nucleic acid may be any nucleic acid, including antisense DNA or RNA. The nucleic acid may encode hormones, enzymes, receptors or drugs of interest. The nucleic acid is selected based upon the desired therapeutic outcome. For example, in the treatment of ischemic diseases, one would select a DNA encoding an angiogenic protein. The nucleic acid may be carried by a microdelivery vehicle such as cationic liposomes and adenoviral vectors. DNA encoding different proteins may be used separately or simultaneously.
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Conlin David G.
Low Christopher S. F.
Resnick David S.
St. Elizabeth's Medical Center of Boston, Inc.
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