Methods and products for mass spectrometric molecular weight det

Details Methods and products for mass spectrometric molecular weight det Methods and products for mass spectrometric molecular weight det

1994-03-28

1997-03-04

Warden, Jill

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

436 86, 436 87, 436 94, G01N 2400

Patent

active

056078595

ABSTRACT:
An improved method for the mass spectrometric determination of the molecular weight of a highly polyionic analyte is provided. The method employs reagents which are highly polyionic but which are of opposite charge to the analytes. The reagents and analytes form a non-covalent complex which is more easily ionized during mass spectrometry and decreases fragmentation of the analyte. Highly polyionic reagents are also provided. The reagents include a multiplicity of highly ionic groups covalently attached along a flexible molecular backbone.

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