Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-04-21
2010-10-19
Zara, Jane (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S001000, C514S002600, C530S387900, C530S388800
Reexamination Certificate
active
07816319
ABSTRACT:
The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is expressed in the lysosomal membrane under certain metabolic conditions. Thus the invention is methods, products, screening assays and kits relating to the manipulation of UCP expression within cellular and intracellular membranes.
REFERENCES:
patent: 4724234 (1988-02-01), Cone, Jr.
patent: 4935450 (1990-06-01), Cone, Jr.
patent: 5556754 (1996-09-01), Singer et al.
patent: 5585363 (1996-12-01), Scanlon et al.
patent: 6113946 (2000-09-01), Szoka, Jr. et al.
patent: 2003/0150022 (2003-08-01), Newell et al.
patent: 2004/0005291 (2004-01-01), Rogers et al.
patent: 2005/0042224 (2005-02-01), Newell
patent: 2005/0074882 (2005-04-01), Newell
patent: 2005/0158333 (2005-07-01), Newell
patent: WO 98/02579 (1998-01-01), None
patent: WO 98/31396 (1998-07-01), None
patent: WO 98/45313 (1998-10-01), None
patent: WO 98/45438 (1998-10-01), None
patent: PCT/US99/06874 (1999-03-01), None
patent: WO 99/53953 (1999-10-01), None
patent: WO 00/47617 (2000-08-01), None
patent: WO 00/78941 (2000-12-01), None
patent: WO 03/031643 (2003-04-01), None
Lobato, MN et al., Trends in Molecular Med., vol. 9, No. 9, pp. 390-396 (2003).
Stayton, PS et al., J. Controlled Release, vol. 65, pp. 203-220 (2000).
Peracchi, A. et al., Rev. Med. Virol., vol. 14, pp. 47-64 (2004).
Chirila, T. et al., Biomaterials, vol. 23, pp. 321-342 (2002).
Agrawal, S. et al., Molecular Med. Today, vol. 6, pp. 72-81 (2000).
Crooke, S., Annu. Rev. Med., vol. 55, pp. 61-95 (2004).
Opalinska, J.B., et al., Nature Reviews, vol. 1, pp. 503-514 (2002).
Branch, A., Trends in Biochem. Sci., vol. 23, pp. 45-50 (1998).
Agrawal, S. et al. Antisense therapeutics: is it as simple as complementary base recognition? Mol Med Today. Feb. 2000;6(2):72-81. Review. Erratum in: Mol Med Today Mar. 2000;6(3):103.
Arsenijevic, D. et al., “Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production”,Nature Genetics, Dec. 2000, pp. 435-439, vol. 26, No. 4.
Asoh, Sadamitsu et al., “Expression of the Apoptosis-Mediator Fas . . . ”, J. Biochem., vol. 120, pp. 600-607, 1996.
Babu, P.G. et al., “Genetic Control of Multisystem Autoimmune . . . ”, Current Topics in Microbiology and Immunology, vol. 122, pp. 154-161, 1985.
Bach, Jean-Francois, “Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease”, Endocrine Society, vol. 15, No. 4, pp. 516-542, Aug. 1994.
Baggetto, LG, “Deviant Energetic Metabolism of Glycolytic Cancer Cells”, Biochimie, vol. 74, pp. 959-974, 1992.
Bhushan, A. et al., “Drug Resistance Results in Alterations . . . ”, Immunology and Cell Biology 76, pp. 350-356, 1998.
Billingham, Dr. R. E. et al., “Actively Acquired Tolerance' of Foreign Cells”, Nature, vol. 172, No. 4379, pp. 603-606, Oct. 3, 1953.
Birnboim, H. Chaim and Jagdeep K. Sandhu, “Levels of DNA Strand Breaks . . . ”, Journal of Cellular Biochemistry, vol. 66, pp. 219-228, 1997.
Böhme, J. et al., “Transgenic Mice with I-A on Islet Cells . . . ”, Science, vol. 244, pp. 1179-1183, Jun. 9, 1989.
Bonfoco, Emanuela et al., “Inducible Nonlymphoid Expression of Fas . . . ”, Immunity, vol. 9, pp. 711-720, Nov. 1998.
Bouillaud, F. et al. A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein. EMBO J. Apr 15, 1994;13(8):1990-7.
Branch, A.D. A good antisense molecule is hard to find. Trends Biochem Sci. Feb. 1998;23(2):45-50. Review.
Burrows, F.J. et al. “A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors,” Cancer Research, 52(21), Nov. 1, 1992, pg. 5954-62, Abstract.
Caldwell, Kevin K. et al., “Evaluation of Methods for the Isolation . . . ”, Analytical Biochemistry, vol. 175, pp. 177-190, 1988.
Cambier, John C. et al., “Ia Binding Ligands and cAMP Stimulate Nuclear Translocation of PKC in B Lymphocytes”, Nature, vol. 327, pp. 629-632, Jun. 18, 1987.
Chien, Millie M. et al., “Fas-induced B Cell Apoptosis Requires . . . ”, Journal of Biological Chemistry, vol. 274, pp. 1-8, 1999.
Chirila, T.V. et al., The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. Jan. 2002;23(2):321-42. Review.
Chisari, Francis V. et al., “Molecular Pathogenesis of Hepatocellular Carcinoma . . . ”, Cell, vol. 59, pp. 1145-1156, Dec. 22, 1989.
Clément, Marie-Véronique and Ivan Stamenkovic, “Superoxide Anion Is A Natural . . . ”, EMBO Journal, vol. 15, No. 2, pp. 216-225, 1996.
Conceição-Silva, Fatima et al., “The Resolution of Lesions Induced . . . ”, Eur. J. Immunol., vol. 28, pp. 237-245, 1998.
Cosgrove, Dominic et al., “Evaluation of the Functional Equivalence of . . . ”, J. Exp. Med., vol. 176, pp. 629-634, Aug. 1992.
Cosgrove, Dominic et al., “Mice Lacking MHC Class II Molecules”, Cell, vol. 66, pp. 1051-1066, Sep. 6, 1991.
Cossarizza, Andrea et al., “Mitochondrial Modification During Rat . . . ”, Experimental Cell Research, vol. 214, pp. 323-330, 1994.
Craighead, John E. et al., “Diverse Patterns of Immune and Non-Immune . . . ”, Journal of Autoimmunity, vol. 3 (Supplement), pp. 27-29, 1990.
Creech, Elizabeth A. et al., “MHC Genes Modify Systemic Autoimmune Disease: The Role of the I-E Locus”, Journal of Immunology, vol. 156, pp. 812-817, 1996.
Crooke, S. Antisense Res. and Application. pp. 1-50. (Ed. by S. Crooke) Springer-Verlag, 1999.
Dang, Chi V. And Gregg L. Semenza, “Oncogenic Alterations of Metabolism”, TIBS, vol. 24, 1999.
del Carmen Ruiz-Ruiz, María et al., “Activation of Protein Kinase C . . . ”, Eur. J. Immunol., vol. 27, pp. 1442-1450, 1997.
Denis-Pouxviel, Colette et al., “Regulation of Mitochondrial Hexokinase in Cultured . . . ”, Biochimica et Biophysica Acta, vol. 902, pp. 335-348, 1987.
Desbarats, Julie et al., “Fas (CD95) Expression and Death-Mediating . . . ”, Proc. Natl. Acad. Sci. USA, vol. 93, pp. 11014-11018, Oct. 1996.
Desbarats, Julie et al., “Newly Discovered Role for Fas Ligand . . . ”, Nature Medicine, vol. 4, No. 12, pp. 1377-1382, Dec. 1998.
Eliopoulos, AG et al. “CD40 Stimulation Augments Apoptosis in Carcinoma Cell Lines,”J. Cellular Biochem, (supplemental 19B), Abstract B8-123, pg. 271, 1995.
Fleury, Christophe et al., “Uncoupling Protein-2: A Novel Gene Linked . . . ”, Nature Genetics, vol. 15, pp. 269-272, Mar. 1997.
Freedman, M., et al., γδ T-cell-human glial cell interactions . . . susceptibility to cytolysis, J. Neuroimmunology, 74:143-148, 1997.
Fujihashi, Kohtaro et al., “γ/δ T Cell-deficient Mice Have Impaired Mucosal Immunoglobulin A Responses,” J. Exp. Med., vol. 183, pp. 1929-1935, Apr. 1996.
Garban, Frédéric et al., “Signal Transduction Via Human Leucocyte . . . ”, Experimental Hematology, vol. 26, pp. 874-884, 1998.
Garlid, Kieth D. et al., “The Mechanism of Proton Transport . . . ”, FEBS Letters, vol. 438, pp. 10-14, 1998.
Genestier, L., et al., “Caspase-dependent Ceramide Production in Fas- and HLA Class I-mediated Peripheral T Cell Apoptosis” J. Bio Chem , (1998), 5060-6.
Golshani-Hebroni, Shiva G. and Samuel P. Bessman, “Hexokinase Binding to Mitochondria: A Basis . . . ”, Journal of Bioenergetics and Biomembranes, vol. 29, No. 4, pp. 331-338, 1997.
González-Barroso, M. Mar et al., “The Uncoupling Protein UCP1 Does Not . . . ”, Journal of Biological Chemistry, vol. 273, No. 25, pp. 15528-15532, Jun. 19, 1998.
University of Vermont and State Agricultural College
Wolf Greenfield & Sacks P.C.
Zara Jane
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