Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-10-24
2011-12-20
Vogel, Nancy (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S377000, C435S325000, C435S368000
Reexamination Certificate
active
08080420
ABSTRACT:
Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
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Helms et al. (2001) Mol. Cell. Neurosci. 17:671-682.
Zheng et al. (2000) Nature Neurosci. 3:580-586.
Li (2003) Nature Med. 9:1293-1299.
pRK5 sequence and plasmid map, http://www.addgene.org/pgvec1?f=v&cmd=viewvecseq&from=&soid=5506&view=Draw, Addgene Inc. (2003-2007), downloaded Feb. 27, 2008.
Entrez Nucleotide Sequence database entry for accession No. D43694, www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=994770, downloaded Feb. 25, 2008.
Warchol et al. (1993) Science 259:1619-1622.
Alvarez Angel
Marutle Amelia
Sugaya Kiminobu
Beusse Wolter Sanks Mora & Maire, P.A.
University of Central Florida Research Foundation Inc.
Van Dyke Timothy H.
Vogel Nancy
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