Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-02-17
2011-10-11
Goddard, Laura B (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C536S024300
Reexamination Certificate
active
08034577
ABSTRACT:
Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.
REFERENCES:
patent: 5491224 (1996-02-01), Bittner et al.
patent: 5756696 (1998-05-01), Gray et al.
patent: 6174681 (2001-01-01), Halling et al.
patent: 6376188 (2002-04-01), Halling et al.
patent: 02/066685 (2002-08-01), None
Riegman et al. (Cancer Research vol. 61,pp. 3164-3170, 2001).
Barrett et al. (PNAS vol. 101, pp. 17765-17770, Dec. 2004).
Wang et al. (Acta Cytologica vol. 35, pp. 199-203, 1991). Abstract only.
van Dekken et al. (Cancer Research, vol. 59, pp. 748-752, 1999).
Molecular Cytogenetics : Protocols and Applications (2002),Y.-S. Fan, Ed., Chapter 2, “Labeling Fluorescence in Situ Hybridization Probes for Genomic Targets,” L. Morrison et al., p. 21-40, Humana Press.
Sokolova IA, et al., The development of a multitarget, multicolor fluorescence in situ hybridization assay for the detection of urothelial carcinoma in urine, J. Molecular Diagnostics, 2:116-123, 2000.
Riegman, P.H.J. et al. Genomic alterations in malignant transformation of Barrett's esophagus. Cancer Res. Apr. 1, 2001;61(7):3164-70.
Krishnadath K.K. et al. Detection of genetic changes in Barrett's adenocarcinoma and Barrett's esophagus by DNA in situ hybridization and immunohistochemistry.Cytometry. Feb. 1, 1994;15 (2):176-84.
Ishizuka T. et al. Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH. Biochem Biophys Res Commun. Aug. 9, 2002;296(1):152-5.
Mimori K. et al. Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. Ann Oncol. Feb. 2004;15(2):236-41.
Fahmy, Mona et al: “Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc. May 2004, vol. 17, No. 5, pp. 588-596.
Krishnadath, Sheila et al: “Detection of cytogenetic abnormalities by multi-color FISH in brush cytology specimens of Barrett's estophagus”. Gastroenterology, Elsevier, Philadelphia, PA, vol. 122, No. 4 Suppl. 1, Apr. 1, 2002, p. A289.
El Gabry E A et al: “Chromosome and gene copy alterations in Barrett's Esophagus (BE)-Associated superficial esophageal adenocarcinoma: Fluorescence in Situ Hybridization (FISH) study” Modern Pathology, vol. 18, No. Suppl. Jan. 1, 2005, p. 102A & 94th Annual Meeting of the United States and Canadian Academy of Pathology; San Antonio, TX, USA; Feb. 26-Mar. 4, 2005.
De Pender A M G et al: “Evaluationof oncogene amplification in intact and truncated cell nuclei of gastro-esophageal cancer cell lines by DNA in situ hybridisation”, ACTA Histochemica, Elsevier, vol. 103, No. 2, Jan. 1, 2001, pp. 127-138.
Brankley Shannon
Halling Kevin
Morrison Larry E.
Abbott Laboratories Inc.
Farrell Kevin M.
Goddard Laura B
Mayo Foundation for Medical Education and Research
Natarajan Meera
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