Methods and pharmaceutical compositions for healing wounds

Details Methods and pharmaceutical compositions for healing wounds Methods and pharmaceutical compositions for healing wounds

2008-07-22

2008-07-22

Angell, Jon E. (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07402571

ABSTRACT:
A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of an agent for either enhancing PKC production and/or enhancing PKC activation; and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.

REFERENCES:
patent: 4673649 (1987-06-01), Weimar
patent: 4833257 (1989-05-01), Pettit et al.
patent: 4940660 (1990-07-01), Hirai
patent: 5145679 (1992-09-01), Hinson
patent: 5461030 (1995-10-01), Lindenbaum
patent: 5591709 (1997-01-01), Lindenbaum
patent: 5770228 (1998-06-01), Edwards et al.
patent: 5869037 (1999-02-01), Crystal et al.
patent: 6096288 (2000-08-01), Roth
patent: 6319907 (2001-11-01), Ferguson
patent: 6403656 (2002-06-01), Rivier
patent: 6541447 (2003-04-01), Dawson
patent: 6582713 (2003-06-01), Newell et al.
patent: 6737241 (2004-05-01), Nolan et al.
patent: 2002/0119914 (2002-08-01), Zhu et al.
patent: 0561330 (1993-09-01), None
patent: 0679402 (1995-02-01), None
patent: WO 85/05036 (1985-11-01), None
patent: WO 90/11071 (1990-10-01), None
patent: WO 92/18147 (1992-10-01), None
patent: WO 93/25660 (1993-12-01), None
patent: WO 96/09810 (1996-04-01), None
patent: WO 96/20724 (1996-07-01), None
patent: WO 96/23522 (1996-08-01), None
patent: WO 99/18920 (1999-04-01), None
patent: WO 99/35283 (1999-07-01), None
patent: WO 9935283 (1999-07-01), None
patent: WO 01/76650 (2001-10-01), None
patent: WO 02/17980 (2002-03-01), None
patent: WO 02/009639 (2002-07-01), None
patent: WO 02/072092 (2002-09-01), None
patent: WO 2005/007072 (2005-01-01), None
Database on NCBI, Genbank Accession No. L07860 (Aris et al.), Nov. 2, 1993.
Perletti et al. (Oncogene, 1998; vol. 16, pp. 3345-3348).
Mischak et al. (Journ, Biol. Chem. 1993, vol. 268(9), pp. 6090-6096).
Pancreatic and Duodenal Homeobox Gene 1 Induces Expression of Insulin Genes in Liver and Ameliorates Streptozotocin-Induced Hyperglycemia, Ferber et al., Nature Medicine, vol. 6, No. 5, May 2000, pp. 568-572.
Epidermis AS Target for In-Vivo Gene-Therapy, Hengge et al., Journal of Investigative Dermatology, vol. 105, No. 3, Sep. 1995, pp. 448.
Ex Vivo and In Vivo Gene Transfer to the Skin Using Replication-Deficient Recombinant Adenovirus Vectors, Setoguchi, et al., The Journal of Investigative Dermatology, vol. 102, No. 4, Apr. 1994, pp. 415-421.
Induction of Differentiation in Normal Human Keratinocytes by Adenovirus-Mediated Introduction of the η and δ Isoforms of Protein Kinase C, Ohba et al., Molecular and Cellular Biology, Sep. 1998, vol. 18, No. 9, pp. 5199-5207.
Servold, et al, Growth Factor Impact on Wound Healing, Clinics in Podiatric Medicine and Surgery, vol. 8, No. 4, Oct. 1991, pp. 937-953.
Taran, et al., Improved Vitality of Experimental Random Dorsal Skin Flaps in Rats Treated with Enriched Cell Culture Medium, Plastic and Reconstructive Surgery, vol. 104, No. 1, Jul. 1999, pp. 148-151.
Jeschke et al., IGF-I Gene Transfer in Thermally Injured Rats, Gene Therapy, (1999) G. pp. 1015-1020.
Spravchikov, et al., Glucose Effects on Skin Keratinocytes, Implications for Diabetes Skin Complications, Diabetes, vol. 50, Jul. 2001, pp. 1627-1635.
Andre et al., Protein Kinases C-γ and -δ are Involved in Insulin-like Growth Factor I-Induced Migration of Colonic Epithelial Cells, Gastroenterology, 1999;116, pp. 64-77.
Shen et al., PKCδ Activation-A Divergence Point in the Signaling of Insulin and IGF-1-Induced Proliferation of Skin Keratinocytes, Diabetes, vol. 50, Feb. 2001, pp. 255-264.
Pittelkow et al., Serum-free Culture of Normal Human Melanocytes: Growth Kinetics and Growth Factor Requirements, Journal of Cellular Physiology, 140:566-576(1989).
Jeschke, Effect of Multiple Gene Transfers of Insulinlike Growth Factor I Complementary DNA Gene Constructs in Rats After Thermal Injury, Arch Surg. 1999;134:1137-1141.
Bitar et al., Insulin and Glucocorticoid-dependent Suppression of the IGF-I System in Diabetic Wounds, Surgery, vol. 127, No. 6, pp. 687-695, Jun. 2000.
Wertheimer et al., The Regulation of Skin Proliferation and Differentiation in the IR Null Mouse: Implications for Skin Complications of Diabetes, Endocrinology, vol. 142, No. 3, pp. 1234-1241, Mar. 2001.
Braiman, et al., Tyrosine Phosphorylation of Specific Protein Kinase C Isoenzymes Participates in Insulin Stimulation Glucose Transport in Primary Cultures of Rat Sketal Muscle, Diabetes, vol. 48, Oct. 1999, pp. 1922-1929.
Braiman, Protein Kinase Cδ Mediates Insulin-Induced Glucose Transport in Primary Cultures of Rat Skeletal Muscle, Molecule Endocrinology, vol. 13, No. 12, pp. 2002-2012.
Ohba et al., Induction of Differentiation in Normal Human Keratinocytes by Adenovirus-Mediated Introduction of the η and δ Isoforms of Protein Kinase C, Mollecular and Cellular Biology, Sep. 1998, vol. 18, No. 9, pp. 5199-5207.
Lindenbaum et al., Serum-free Cell Culture Medium Induces Acceleration of Wound Healing in Guinea-Pigs, Burns, vol. 21, No. 2, 1995, pp. 110-115.
Spravchikov, et al., The Interactive Effects of Hyperglycemia, Insulin and IFG-1 in Murine Skin Cells-An IR-Null Mouse Model, Dept. of Pathology, Sackler School of Medicine, Tel Aviv University, Israel, (Abstract), Aug. 2000.
Shen, et al., Protein Kinase C Activation: A Divergence Point in the Signaling of Insulin and Insulin Like Growth Factor-1 Induced Proliferation of Skin Keratinocytes, Bar Ilan University, Ramat Gan, Israel, (Abstract), Apr. 2000.
Wertheimer, et al., The Effects of Insulin Signaling on Skin Proliferation and Differentiation—Lessons from the IR- and IRS1 Null Models, Dept. of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, (Abstract), Aug. 2000.
Al, et al. “The experimental study of bone marrow mesenchymal stem cells on the repair of skin wound combined with local radiation injury”,Zhonhghua Yi Xue Za Zhi, 82(23), (2002), pp. 1632-1636; Pubmed Abstract PMID 12667374.
Alessenko, et al. “Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration”,Blochem. Biophys, Commun., 182, (1992), pp. 1333-1339.
Bajou, et al. “Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization”,Nat. Med., 4 (1998), pp. 923-928.
Bandyopadhyay, et al. “Effects of transiently expressed atypical (ζ, λ), conventional (α, β), and novel (ε, Ε) [. . ]”,Biochem. J., 337 (1999), pp. 461-470.
Benes, et al. “The C2 domain of PKC δ is a phosphotyrosine binding domain”,Cell, 121 (2005), pp. 271-280.
Chida, et al. “The η isoform of protein kinase C is localized on rough endoplasmic reticulum”,Mol. Cell Biol. 14 (1994), pp. 3782-3790.
Denning, et al. “Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium”,Cell Growth Differ., 6 (1995), pp. 149-157.
Dlugosz and Yuspa, “Coordinate changes in gene expression which mark the spinous to granular call transition in epidermis are regulated by protein kinase C”J. Cell. Biol., 120 (1993), pp. 217-225.
Formisano, et al. “In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing”,J. Biol, Chem., 273 (1998), pp. 12197-13202.
Gschwendt “Protein kinase Cδ”,Eur. J. Biochem., 259 (1999), pp. 555-564.
Hofmann “The potential for isoenzyme-selective modulation of protein kinase C”,The FASEB J., 11 (1997), pp. 649-669.
Madibally, et al. “Influence of insulin therapy on burn wound healing in rats”,J. Surg. Res., 109 (2003), pp. 92-100.
Michalik, et al. “Impaired skin wound healing in perioxisome proliferator-activated receptor (PRAR) and PPAR mutant mice”,J. Cell. Biol., (154) (2001) pp. 799-814.
Mischak, et al. “Phorbol ester- induced myeloid differentiation is mediated by p

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