Methods and molecules useful for identifying molecules that...

Details Methods and molecules useful for identifying molecules that... Methods and molecules useful for identifying molecules that...

2005-01-25

2005-01-25

Saunders, David (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S009200

Reexamination Certificate

active

06846643

ABSTRACT:
The present invention relates generally to a method for identifying molecules that bind the R7.1 epitope of LFA-1 or bind LFA-1 such that the R7.1 epitope is modified. The present invention further relates to a method for determining occupancy of the LFA-1 receptor by molecules that bind to the R7.1 epitope or bind LFA-1 such that the R7.1 epitope is modified after administration to a subject. The present invention further relates to molecules useful in the methods of the invention.

REFERENCES:
Argenbright, L.W. et al, “Monoclonal antibodies to the leukocyte membrane CD18 glycoprotein complex and to intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits”, Journal of Leukocyte Biology, 1991, vol. 49, pp. 253-257.
Harlow, E. et al, “Antibodies: a laboratory manual”, 1988, Cold Spring Harbor Laboratory, pp. 567-569, 583 and 590. See especially p. 567, first paragraph and p. 590, first two paragraphs.

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