Methods and means for non-invasive, dynamic tracking of cardiac

Details Methods and means for non-invasive, dynamic tracking of cardiac Methods and means for non-invasive, dynamic tracking of cardiac

1992-09-22

1993-11-30

Kamm, William E.

Surgery

Truss

Pad

A61B 50468

Patent

active

052656179

ABSTRACT:
A method and apparatus for the non-invasive, dynamic tracking and diagnosing of cardiac vulnerability to ventricular fibrillation are disclosed. T-wave alternans and heart rate variability are simultaneously evaluated. T-wave alternation is an absolute predictor of cardiac electrical instability. Heart rate variability is a measure of autonomic influence, a major factor in triggering cardiac arrythmias. By simultaneously analyzing both phenomena, the extent and cause of cardiac vulnerability can be assessed. The method includes the following steps. An ECG signal is sensed from a heart. The T-wave portions of the ECG signal are analyzed to estimate an amplitude of beat-to-beat alternation. The amplitude of beat-to-beat alternation represents cardiac electrical instability. The R-R intervals are analyzed to estimate a magnitude of a high frequency component of heart rate variability and to estimate a magnitude of a low frequency component of heart rate variability. The high frequency component indicates parasympathetic activity. The low frequency component indicates combined sympathetic activity and parasympathetic activity. The amplitude of beat-to-beat alternation, the high frequency component of heart rate variability, and the low frequency component of heart rate variability are simultaneously analyzed to diagnose cardiac electrical instability.

REFERENCES:
patent: 4492235 (1985-01-01), Sitrick
patent: 4583553 (1986-04-01), Shah et al.
patent: 4680708 (1987-07-01), Ambes et al.
patent: 4796638 (1989-01-01), Sasaki
patent: 5020540 (1991-06-01), Chamcou
patent: 5092341 (1992-03-01), Kelen
patent: 5109862 (1992-05-01), Kelen et al.
B. Nearing et al., "Dynamic Tracking of Cardiac Vulnerability by Complex Demodulation of the T-Wave," Science, vol. 252, Apr. 19, 1991, pp. 437-440.
G. Myers et al., "Power Spectral Analysis of Heart Rate Variability in Sudden Cardiac Death: Comparison to Other Methods," IEEE Transactions on Biomedical Engineering, vol. BME-33, No. 12, Dec. 1986, pp. 1149-1156.
S. Akselrod et al., "Power Spectrum Analysis of Heart Rate Fluctuation: A Quantitative Probe of Beat-to-Beat Cardiovascular Control," Science, vol. 213, Jul. 10, 1981, pp. 220-222.
M. Appel et al., "Beat to Beat Variability in Cardiovascular Variables: Noise or Music?," Journal of the American College of Cardiology, vol. 14, No. 5, Nov. 1, 1989, pp. 1139-1148.
W. Orr et al., "A 90-Min Cardiac Biorhythm: Methodology and Data Analysis Using Modified Periodograms and Complex Demodulation," IEEE Transactions on Biomedical Engineering, vol. BME-21, No. 2, Mar. 1974, pp. 130-143.
S. Shin et al., "Assessment of Autonomic Regulation to Heart Rate Variability by the Method of Complex Demodulation," IEEE Computers in Cardiology, 1988, pp. 147-150.

Affiliated with

Also associated with

Rating

Methods and means for non-invasive, dynamic tracking of cardiac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and means for non-invasive, dynamic tracking of cardiac , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and means for non-invasive, dynamic tracking of cardiac will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2088768