Methods and means for modulating PGE synthase activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase

Reexamination Certificate

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C435S183000, C435S190000

Reexamination Certificate

active

10962155

ABSTRACT:
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.

REFERENCES:
patent: 6395502 (2002-05-01), Jakobsson et al.
patent: WO 9914356 (1999-03-01), None
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Dr. Shalinsky et al. Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin. PubMEd Query. (1989) p. 1.
Toshiya Ogorochi, et al. Purification and Properties of Prosaglandin H-E Isomerase from the Cytosol of Human Brain: Identification as Anionic Forms of Glutathione S-Transferase. Journal of Neurochemistry (1987) 48:900-909.
Yasuhito Tanake et al. Immunochemical and Kinetic Evidence for Two Different Prostaglandin H-Prostaglandin E Isomerase in Sheep Vesicular Gland Microsomes . . . Journal of Biological Chemistry (Jan. 25, 1987) 262: 1374-1381.
Kikuko Watanabe et al. Two Types of Microsomal Prostaglandin E Synthase: Glutathione-Dependent and—Independent Prostaglandin E Synthases. Biochemical and Biophysical Research Communications (1997) 235: 148-152.
Per-Johan Jakobsson et al. Identification of Human, prostaglanin E synthase: A microsomal, potential novel drug target. Proc. Nat l. Acad. Sci.(1999) 96:7220-7225.
XP-002132552 1 Sheet of Sequence, Nov. 1997.

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