Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2006-06-27
2006-06-27
Monshipouri, Maryam (Department: 1653)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S183000, C435S189000, C530S350000
Reexamination Certificate
active
07067296
ABSTRACT:
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
REFERENCES:
patent: 6432640 (2002-08-01), Polyak et al.
patent: WO 9914356 (1999-03-01), None
Polyak et al., Nature, 1997, 398, 300-305.
Kornelia Polyak, et al. A model for p53-induced apoptosis. Letters to Nature (Sep. 18, 1997) 389:300-305.
D.R. Shalinsky et al. Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin. PubMEd Query. (1989) p. 1.
Toshiya Ogorochi, et al. Purification and Properties of Prosaglandin H-E Isomerase from the Cytosol of Human Brain: Identification as Anionic Forms of Glutathione S-Transferase. Journal of Neurochemistry (1987) 48:900-909.
Yasuhito Tanaka et al. Immunochemical and Kinetic Evidence for Two Different Prostaglandin H-Prostaglandin E Isomerase in Sheep Vesicular Gland Microsomes . . . Journal of Biological Chemistry (Jan. 25, 1987) 262: 1374-1381.
Kikuko Watanabe et al. Two Types of Microsomal Prostaglandin E Synthase: Glutathione-Dependent and -Independent Prostaglandin E Synthases. Biochemical and Biophysical Research Communications (1997) 235: 148-152.
Per-Johan Jakobsson et al. Identification of Human, prostaglandin E synthase: A microsomal, potential novel drug target. Proc. Nat l. Acad. Sci.(1999) 96:7220-7225.
XP-002132552 1 Sheet of Sequence.
Ford-Hutchinson Anthony
Jakobsson Per-Johan
Mancini Joseph
Morgenstern Ralf
Samuelsson Bengt
Dann Dorfman Herrell and Skillman
Karolinska Innovations AB
Monshipouri Maryam
LandOfFree
Methods and means for modulating PGE synthase activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and means for modulating PGE synthase activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and means for modulating PGE synthase activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3639046