Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-11-08
2005-11-08
Murphy, Joseph (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007200, C530S300000
Reexamination Certificate
active
06962792
ABSTRACT:
p21WAF1interacts with cyclin D1 and Cdk4. Peptide fragments of p21 inhibit the interaction and/or affect Cdk4 activity. The peptides, derivative peptides and non-peptidyl mimetics thereof are useful in affecting activity of Cdk4, such as RB phosphorylation, and cellular proliferation, indicative of therapeutic usefulness in treatment of tumours and other hyperproliferative disorders. Assay and screening methods allow identification of such modulators, especially inhibitors, of Cdk4 activity.
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Ball Kathryn Lindsay
Lane David Philip
Cyclacel Limited
DeConti, Jr. Giulio A.
Kanik Cynthia L.
Lahive & Cockfield LLP
Murphy Joseph
LandOfFree
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