Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...
Patent
1995-06-06
1998-06-30
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Nucleoproteins, e.g., chromatin, chromosomal proteins,...
514 12, 514 14, 435 691, 435 697, A61K 3816
Patent
active
057735832
ABSTRACT:
Disclosed are DNA sequences encoding novel DNA binding proteins implicated in regulation of early stages of cell growth. Illustratively provided are human and mouse origin DNA sequences encoding early growth regulatory ("Egr") proteins which include "zinc finger" regions of the type involved in DNA binding. Also disclosed is a detailed analysis of the structure and function of the early growth regulatory protein, Egr-1, delineating independent and modular activation, repression, DNA-binding, and nuclear localization activities. Also disclosed are immunological methods and materials for detection of Egr proteins and hybridization methods and materials for detection and quantification of Egr protein related nucleic acids.
REFERENCES:
Sukhatme et al. (1988) A Zinc Finge-Encoding Gene Coregulated with c-fos during Growth and Differentiation, and after Cellular Depolarization. Cell, vol. 53, pp. 37-43.
Joseph et al. (1988) Molecular Cloning, Sequencing and Mapping of EGR2, a Human Early Growth Response Gene Encoding a Protein with "Zinc Finger" Structure. Proc. Natl. Acad. Sci. USA. vol. 85, pp. 7164-7168.
Harris et al. (1988) Protein Purification Methods A Practical Approach. IRL Press. pp. 57-65.
Carter (1990) Site-Specific Proteolysis of Fusion Proteins. ACS Symp. Ser. vol. 427, Protein Purification: Mol. Mech. Large Scale Processes. pp. 181-193.
Milbrandt (Nov. 1987) Science, vol. 238, pp. 797-799.
Wang et al. (1988) Parenteral Formulations of Proteins and Peptides: Stability and Stabilizers. J. Parenteral Science and Tech. vol. 42, Supplement, pp. S3-S26.
ARCH Development Corporation
Longton Enrique D.
Wax Robert A.
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