Methods and materials relating to IMPDH and GMP production

Details Methods and materials relating to IMPDH and GMP production Methods and materials relating to IMPDH and GMP production

1988-08-12

1997-09-09

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435 89, 4351723, 4352523, 43525233, 4353201, 435358, 435325, 536 232, 536 235, C12N 1552, C12N 121, C12N 1563, C12N 1585

Patent

active

056655835

ABSTRACT:
Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.

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