Methods and materials relating to CD8-tropic HIV-1

Details Methods and materials relating to CD8-tropic HIV-1 Methods and materials relating to CD8-tropic HIV-1

2005-05-03

2005-05-03

Stucker, Jeffrey (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S350000, C530S826000, C536S023720

Reexamination Certificate

active

06887977

ABSTRACT:
The present invention relates to human immunodeficiency viruses 1 (HIV-1) that infect CD8-positive cells using CD8 as a receptor, to detection methods for the viruses and to prophylactic and therapeutic methods for infection by the viruses.

REFERENCES:
patent: 20020182592 (2002-12-01), Petropoulos et al.
patent: WO 0071561 (2000-11-01), None
Cullen, A New Entry Route for HIV,Nature Medicine, 7: 20-21 (2001).
Dumonceaux et al., Spontaneous Mutations in the env Gene of the Human Immunodeficiency Virus Type 1 NDK Isolate are Associated with a CD4-Independent Entry Phenotype,Journal of Virology, 72: 512-19 (1998).
Flamand et al., Activation of CD8+T Lymphocytes through the T Cell Receptor turns on CD4 Gene Expression: Implications for HIV Pathogenesis,Proc. Natl. Acad. Sci. USA, 95: 3111-3116 (1998).
Hoffman et al., HIV Type I Envelope Determinants for use of the CCR2b, CCR3, STRL33, and APJ Coreceptors,Proc. Natl. Acad. Sci. USA, 95: 11360-11365 (1998).
Huang et al., Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant,Journal of Virology, 72: 2047-2054 (1998).
Kaneko et al., Human Immunodeficiency Virus Type 2 Envelope Glycoprotein Binds to CD8 as Well as to CD4 Molecules on Human T Cells,Journal of Virology, 71: 8918-922 (1997).
Kitchen et al., Costimulation of Naïve CD8+Lymphocytes Induces CD4 Expression and Allows Human Immunodeficiency Virus Type 1 Infection,Journal of Virology, 72: 9054-9060 (1998).
Kolchinsky et al., Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication,Journal of Virology, 73: 8120-8126 (1999).
Livingstone et al., Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1,Lancet, 348: 649-654 (1996).
Saha et al., Generation of CD4+and CD8+T-cell clones from PBLs of HIV-1 infected subjects using herpesvirus saimiri,Nature Medicine, 2:1272-1275 (1996).
Saha et al., Endogenous Production of β-Chemokines by CD4+, but Not CD8+, T-Cell Clones Correlates with the Clinical State of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals and May Be Responsible for Blocking Infection with Non-Syncytium-Inducing HIV-1 In Vitro,Journal of Virology, 72: 876-881 (1998).
Saha et al., Isolation of primary HIV-1 that target CD8+T Lymphocytes using CD8 as a receptor,Nature Medicine, 7: 65-72 (2001).
Saha et al., Evidence of Productively Infected CD8+T Cells in Patients With AIDS: Implications of HIV-1 Pathogenesis,Journal of Acquired Immune Deficiency Syndromes, 26: 199-207 (2001).
Semenzato et al., CD8+T Lymphocytes in the Lung of Acquired Immunodeficiency Syndrome Patients Harbor Human Immunodeficiency Virus Type 1,Blood, 85: 2308-2314 (1995).
Shankarappa et al., Consistent Viral Evoluntionary Changes Associated with the Progression of Human Immunodeficiency Virus Type1 Infection,Journal of Virology, 73: 10489-10502 (1999).

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