Methods and materials relating to a bi-metallic cross-linking sp

Details Methods and materials relating to a bi-metallic cross-linking sp Methods and materials relating to a bi-metallic cross-linking sp

1994-01-24

1996-07-09

Nazario-Gonzales, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514 6, 514501, 514496, 556 28, 556136, 556137, A61K 3128, C07F 1900, C07F 1500, C07F 310

Patent

active

055345425

ABSTRACT:
Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M.sub.1 is a metal ion species capable of forming a complex of coordination number four or coordination number six; wherein L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are each independently a halide, ammonia, dimethyl sulfoxide, carboxylate, thiolate, imidazole, a nucleobase, or an empty coordination site, provided that no more than two of L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are empty coordination sites; wherein M.sub.2 is a metal ion species capable of forming a complex of coordination number two with a first ligand that is a hydrocarbon moiety and a second ligand that is kinetically lablie; and wherein n is an integer from two to nine. Also disclosed are cross-linked species, methods of preparing the crosslinking reagents of the invention, and methods for their use in tissue-specific targeting of anti-tumor agents.

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