Methods and materials for treating inflammatory conditions

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S403000, C530S806000

Reexamination Certificate

active

10724662

ABSTRACT:
The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5awithin a mammal by reducing the amount of total and receptor bound C5ain the mammal.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 6534058 (2003-03-01), Fung et al.
patent: 7063847 (2006-06-01), Sanderson et al.
patent: 0 300 740 (1989-01-01), None
patent: WO 96/39503 (1996-12-01), None
patent: WO 01/15731 (2001-03-01), None
patent: WO 03/015819 (2003-02-01), None
Stafslien, DK et al. J. Bacteriol. [2000] 182(11):3254-3258.
Oshima, M et al. Immunol. Lett. [1998] 60:7-12.
Na, B-K et al. Clin Diag Lab. Immunol. [1999] 6(3):429-433.
GenBank Accession No. M57729.
Andersson et al., “Collagen-induced arthritis (CIA) is an experimental model for autoimmune arthritis which is induced in rodents by immunization with type II collagen (CII),”Immunogenetics, 1992, 35:71-72.
Carney and Hugli, “Site-specific mutations in the N-terminal region of human C5a that affect interactions of C5a with the neutrophil C5a receptor,”Protein Science, 1993, 2:1391-1399.
Gossler et al., “Transgenesis by means of blastocyst-derived embryonic stem cell lines,”Proc. Natl. Acad. Sci. USA, 1986, 83:9065-9069.
Hennecke et al., “A detailed analysis of the C5a anaphylatoxin effector domain: selection of C5a phage libraries on differentiated U937 cells,”Eur. J. Biochem., 1998, 252:36-44.
Kola et al., “Analysis of the C5a anaphylatoxin core domain using a C5a phage library selected on differentiated U937 cells,”Molecular Immunology, 1999, 36:145-152.
Lo, “Transformation by Iontophoretic Microinjection of DNA: Multiple Integrations Without Tandem Insertions,”Molecular and Cellular Biology, 1983, 3:1803-1814.
Mizuno et al., “Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59,”Clin. Exp. Immunol., 2000, 119:368-375.
Mulligan et al., “Requirement and Role of C5a in Acute Lung Inflammatory Injury in Rats,”J. Clin. Invest., 1996, 98:503-512.
Pellas et al., “Novel C5a Receptor Antagonists Regulate Neutrophil Functions In Vitro and In Vivo,”J. Immunol., 1998, 160:5616-5621.
Sambrook et al.,Molecular Cloning, 1989, 2ndedition, Cold Spring Harbor Laboratory, Plainview, NY, Sections 7.39-7.52.
Schnieke et al., “Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts,”Science, 1987, 278:2130-2133.
Siciliano et al., “Two-site binding of C5a by its receptor: An alternative binding paradigm for G protein-coupled receptors,”Proc. Natl. Acad. Sci. USA, 1994, 91:1214-1218.
Svensson et al., “IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis,”Eur. J. Immunol., 2002, 32:2944-2953.
Thompson et al., :“Germ Line Transmission and Expression of a Corrected HPRT Gene Produced by Gene Targeting in Embryonic Stem Cells,”Cell, 1989, 56:313-321.
Toth et al., “The pharmacophore of the human C5a anaphylatoxin,”Protein Science, 1994, 3:1159-1168.
Van der Putten et al., “Efficient insertion of genes into mouse germ line via retroviral vectors,”Proc. Natl. Acad. Sci. USA, 1985, 82:6148-6152.
Wang et al., “A Role for Complement in Antibody-Mediated Inflammation: C5-Deficient DBA/1 Mice Are Resistant to Collagen-Induced Arthritis,”J. Immunol., 2000, 164:4340-4347.
Wang et al., “Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease,”Proc. Natl. Acad. Sci. USA, 1995, 92:8955-8959.
Wilken et al., “Specific detection by flow cytometry of histidine-tagged ligands bound to their receptors using a tag-specific monoclonal antibody,”J. Immunol. Meth., 1999, 226:139-145.
Zhang et al., “Solution structure of a unique C5a semi-synthetic antagonist: Implications in receptor binding,”Protein Science, 1997, 6:65-72.
Zhang et al., “Structural Definition of the C5a C Terminus by Two-Dimensional Nuclear Magnetic Resonance Spectroscopy,”PROTEINS: Structure, Function, and Genetics, 1997, 28:261-267.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and materials for treating inflammatory conditions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and materials for treating inflammatory conditions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and materials for treating inflammatory conditions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3938389

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.