Methods and materials for the preparation of metal labelled anti

Details Methods and materials for the preparation of metal labelled anti Methods and materials for the preparation of metal labelled anti

1987-11-06

1992-07-14

Rosen, Sam

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 6, 424 858, 424 8591, 436 64, 436173, 436175, 436547, A61K 4300

Patent

active

051301180

ABSTRACT:
The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.

REFERENCES:
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4634586 (1987-01-01), Goodwin et al.
Esteban et al., "New Method for Chelation of Indium-111 . . . ", J. Nucl. Med. 28(5), 861-870 (1987, May).

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