Methods and materials for producing gene libraries

Details Methods and materials for producing gene libraries Methods and materials for producing gene libraries

1995-02-15

1997-08-12

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 911, 4353201, 536 231, 536 234, C12N 1564, C12P 1934, C07H 2104

Patent

active

056564678

ABSTRACT:
Methods for producing libraries of diverse nucleotide sequences, and libraries of polypeptides encoded thereby, are provided. The nucleotide sequences comprise a first and a second constant region coupled to a coding sequence, wherein the coding sequence is formed by sequentially coupling nucleotides in a mixture of predetermined proportions of A, T, C, and G based upon a known amino acid profile. Libraries of vectors comprising the diverse nucleotide sequences are also provided. DNA and amino acid sequences encoding the libraries are further provided.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5316922 (1994-05-01), Brown et al.
Butt et al., PNAS, 86:2540-2544 (1989).
Edgington, Bio/Technology, 11:285-289 (1993).
Kauffman, J. Theor. Biol., 157:1-7 (1992).
LaBean et al., Protein Science, 2:1249-1254 (1993).
Scott, TIBS, 17:241-245 (1992).
Shatzman et al., Methods in Enzymology, 152:661-673 (1987).
Sjostrom et al., J. Mol. Evol., 22:272-277 (1985).
Waller, J. Mol. Biol., 7, 483-496 (1967).
Yoo et al., J. Biol Chem., 264:17078-17083 (1989).
Arkin and Youvan, Bio/Technology, 10:297-300 (1992).
Bachmair et al., Science, 234:179-186 (1986).
Cwirla, et al., Proc. Natl. Acad. Sci., 87:6378-6382 (1990).
Devlin, et al., Science, 249:404-406 (1990).
Ecker, et al., J. Biol. Chem., 262:14213-14221 (1987).
Edgington, Bio/Technology, 10:137-140 (1992).
Ellington and Szostak, Nature, 346:818-822 (1990).
Geysen, et al., Proc. Natl. Acad. Sci., 81:3998-4002 (1984).
Hodgson, Bio/Technology, 8:1245-1247 (1990).
Horwitz and Loeb, J. Biol. Chem., 263:14724-14731 (1988).
Kaiser, et al., Science, 235:312-317 (1987).
Klapper, Biochem. Biophys. Res. Com., 78:1018-1024 (1977).
Kolaskar, et al., Int. J. Peptide Protein Res., 22:83-91 (1983).
LaBean et al., The FASEB J., Abstract, ASBMB/Biophysical Meeting, vol. 6, No. 1, Jan. 1992.
Ma and Ptashne, Cell, 51:113-119 (1987).
Mandecki, Protein Engineering, 3:221-226 (1990).
Monia, et al., J. Biol. Chem., 264:4093-4103 (1989).
Oliphant and Struhl, Nucl. Acids Res., 16:7673-7683 (1988).
Parmley and Smith, Gene, 73:305 (1988).
Scott and Smith, Science, 249:386-390 (1990).
Tuerk and Gold, Science, 249:386-390 (1990).
Vonderviszt, et al., Int. J. Peptide Protein Res., 27:483-492 (1986).

Affiliated with

Also associated with

Rating

Methods and materials for producing gene libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and materials for producing gene libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and materials for producing gene libraries will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-159515