Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-11-08
2005-11-08
Kunz, Gary (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007200, C435S069100, C435S069500, C436S501000
Reexamination Certificate
active
06962776
ABSTRACT:
The invention provides methods and materials for evaluating cardiovascular conditions (e.g., angina conditions). Specifically, the invention provides methods and materials related to determining whether or not a mammal has at least one unstable plaque. The invention also provides kits for assessing cardiovascular conditions, substantially pure populations of cells, and methods of identifying compounds to treat life-threatening cardiovascular conditions (e.g., unstable angina).
REFERENCES:
Adams, “Molecules in Focus—Thrombospondin-1,”Int. J. Biochem. Cell Biol., 1997, 29(6):861-865.
Adams et al., “Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1,”EMBO J., 1998, 17(17):4964-4974.
Ansel et al., “A chemokine-driven positive feedback loop organizes lymphoid follicles,”Nature, 2000, 406:309-314.
Arai et al., “Cytokines: Coordinators of Immune and Inflammatory Responses,”Annu. Rev. Biochem., 1990, 59:783-836.
Banerjee et al., “Expression of Cdc2 and Cyclin B1 inHelicobacter pylori-Associated Gastric MALT and MAST Lymphoma,”Am. J. Pathol., 2000, 156:217-225.
Biasucci et al., “Elevated Levels of Interleukin-6 in Unstable Angina,”Circulation, 1996, 94:874-877.
Blumgart et al., “Studies on the Relation of the Clinical Manifestations of Angina Pectoris, Coronary Thrombosis, and Myocardial Infarction to the Pathological Findings,”Am. Heart J., 1940, 19:1-91.
Boehm et al., “Cellular Responses to Interferon-γ,”Annu. Rev. Immunol., 1997, 15:749-795.
Bofill et al., “Follicular dendritic cells share a membrane-bound protein with fibroblasts,”J. Pathol., 2000, 191:217-226.
Brack et al., “Glucocorticoid-mediated Repression of Cytokine Gene Transcription in Human Arteritis-SCID Chimeras,”J. Clin. Invest., 1997, 99(12):2842-2850.
Brichard et al., “The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes in HLA-A2 Melanomas,”J. Exp. Med., 1993, 178:489-495.
Browning et al., “Characterization of Surface Lymphotoxin Forms,”J. Immunol., 1995, 154:33-46.
Browning et al., “Signaling through the Lymphotoxin β Receptor Induces the Death of Some Adenocarcinoma Tumor Lines,”J. Exp. Med., 1996, 183:867-878.
Braunwald et al., “Unstable Angina: Diagnosis and Management,” Clinical Practice Guideline No. 10, AHCPR Publication No. 94-0602, May 1994, Rockville, MD: Agency for Health Care Policy and Research and the National Heart, Lung, and Blood Institute, Public Health Service, U.S. Department of Health and Human Services.
Buja and Willerson, “Role of Inflammation in Coronary Plaque Disruption,”Circulation, 1994, 89:503-505.
Burleigh et al., “Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations,”Atherosclerosis, 1992, 96:71-81.
Cannella et al., “Antibodies to lymphotoxin α (LTα) and LTβ recognize different glial cell types in the central nervous system,”J. Neuroimmunol., 1997, 78:172-179.
Chambers and Allison, “Co-stimulation in T cell responses,”Curr. Opin. Immunol., 1997, 9:396-404.
Chesebro et al., “Pathogenesis of Thrombosis in Coronary Artery Disease,”Haemostasis, 1997, 27(Suppl. 1):12-18.
Choi et al., “Interaction ofStaphylococcus aureustoxin “superantigens” with human T cells,”Proc. Natl. Acad. Sci. USA, 1989, 86:8941-8945.
Cooper et al., “Transendothelial migration of neutrophils involves integrin-associated protein (CD47),”Proc. Natl. Acad. Sci. USA, 1995, 92:3978-3982.
Croft, “Activation of naive, memory and effector T cells,”Curr. Opin. Immunol., 1994, 6:431-437.
Cuff et al., “Differential Induction of Adhesion Molecule and Chemokine Expression by LTα3 and LTαβ in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development,”J. Immunol., 1999, 162:5965-5972.
Cyster, “Chemokines and Cell Migration in Secondary Lymphoid Organs,”Science, 1999, 286:2098-2102.
Cyster et al., “Chemokines and B-cell Homing to Follicles,”Current Topics in Microbiology and Immunology, 1999, 246:87-92.
Cyster, “Leukocyte migration: Scent of the T zone,”Curr. Biol., 2000, 10:R30-R33.
Danesh et al., “Chronic infections and coronary heart disease: is there a link?”Lancet, 1997, 350:430-436.
Darnell, “STATs and Gene Regulation,”Science, 1997, 277:1630-1635.
Davies and Thomas, “Plaque fissuring—the cause of acute myocardial infarction , sudden ischaemic death, and crescendo angina,”Br. Heart J., 1985, 53:363-373.
Davies et al., “Intramyocardial platelet aggregation in patients with unstable angina suffering sudden ischemic cardiac death,”Circulation, 1986, 73(3):418-427.
Davies et al., “Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smoth muscle cell content,”Br. Heart J., 1993, 69:377-381.
Daviet and McGregor, “Vascular Biology of CD36: Roles of this New Adhesion Molecule Family in Different Disease States,”Thromb. Haemost., 1997, 78:65-69.
de Feyter et al., “Ischemia-Related Lesion Characteristics in Patients with Stable or Unstable Angina,”Circulation, 1995, 92:1408-1413.
de Servi et al., “Expression of Neutrophil and Monocyte CD11B/CD18 Adhesion Molecules at Different Sites of the Coronary Tree in Unstable Angina Pectoris,”Am. J. Cardiol., 1996, 78:564-568.
De Togni et al., “Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin,”Science, 1994, 264:703-707.
DeWood et al., “Prevelance of Total Coronary Occlusion During the Early Hours of Transmural Myocardial Infarction,”N. Engl. J. Med., 1980, 303(16):897-902.
Dobson et al., “Changes in estimated coronary risk in the 1980s: data from 38 populations in the Who Monica Project,”Ann. Med., 1998, 30:199-205.
Falciani et al., “Elevated Tissue Factor and Tissue Factor Pathway Inhibitor Circulating Levels in Ischaemic Heart Disease Patients,”Thromb. Haemost., 1998, 79:498-499.
Falk et al., “Coronary Plaque Disruption,”Circulation, 1995, 92:657-671.
Farkouh et al., “A Clinical Trial of a Chest-Pain Observation Unit for Patients with Unstable Angina,”N. Eng. J. Med., 1998, 339:1882-1888.
Fehr et al., “Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules,”Int. Immunol., 2000, 12(9):1275-1284.
Förster et al., “Expression of the G-Protein-Coupled Receptor BLR1 Defines Mature, Recirculating B Cells and a Subset of T-Helper Memory Cells,”Blood, 1994, 84(3):830-840.
Förster et al., “A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen,”Cell, 1996, 87:1037-1047.
Förster et al., “CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organis,”Cell, 1999, 99:23-33.
Freni et al., “Focal Lymphocytic Aggregates in Chronic Hepatitis C: Occurrence, Immunohistochemical Characterization, and Relation to Markers of Autoimmunity,”Hepatology, 1995, 22:389-394.
Frieda et al., “Recombinant GST/CD36 Fusion Proteins Define a Thrombospondin Binding Domain,”J. Biol. Chem., 1995, 270(7):2981-2986.
Fu et al., “Lymphotoxin-α (LTα) Supports Development of Splinic Follicular Structure That Is Required for IgG responses,”J. Exp. Med., 1997, 185:2111-2120.
Fuster et al., “The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes,”N. Engl. J. Med., 1992, 326(5):310-31
Goronzy Jorg J.
Kopecky Stephen L.
Weyand Cornelia M.
Fish & Richardson P.C. P.A.
Hamud Fozia
Kunz Gary
Mayo Foundation for Medical Education and Research
LandOfFree
Methods and materials for evaluating cardiovascular conditions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and materials for evaluating cardiovascular conditions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and materials for evaluating cardiovascular conditions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3498836