Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-10-03
1996-11-12
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 792, 435973, 435975, 436501, 436506, 436508, 436518, 436531, 436808, 436809, C12Q 168
Patent
active
055739113
ABSTRACT:
The subject invention pertains to a method of binding proteins and double-stranded DNA to the same membrane matrix. The DNA bound to the membrane matrix remains in double-stranded form. The subject invention further concerns an assay procedure for detecting antibodies, such as autoimmune antibodies, in a biological sample that are immunoreactive with the proteins and double-stranded DNA attached to a membrane matrix. The subject invention provides a single assay system that allows for the determination of antinuclear antibody specificities which can be used to aid in the diagnosis and monitoring of autoimmune diseases.
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Pieti Lisa M.
Victor Jacob
Lifecodes Corp.
Spiegel Carol A.
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