Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-11-03
1997-12-09
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530351, 530380, A61K 3816, A61K 3819, C07K 1400, C07K 1452
Patent
active
056960867
ABSTRACT:
The invention provides methods for stimulating megakaryocyte maturation and thrombocyte production using macrophage stimulating protein ("MSP"). In the methods, an effective amount of MSP can be administered in vivo, or alternatively, be used to stimulate maturation of megakaryocytes and produce thrombocytes in vitro. Methods for treating thrombocytopenia in a mammal with MSP are also provided. Kits and articles of manufacture which include MSP are further provided.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 5219991 (1993-06-01), Lenoard et al.
patent: 5227158 (1993-07-01), Jardieu
patent: 5316921 (1994-05-01), Godowski et al.
patent: 5328837 (1994-07-01), Godowski et al.
patent: 5352680 (1994-10-01), Portoghese et al.
patent: 5362716 (1994-11-01), Kmiecik et al.
patent: 5547931 (1996-08-01), Potempa
Gordon MS, Hoffmann G, "Growth Factors Affecting Human Thromobocytopoiesis: Potential AGents for the Treatment of Thromocytopenia", Blood, vol. 80, No. 2, pp. 302-307, Jul. 1992.
Hoffman Ronald, "Regulation of Megakaryocytopoiesis", Blood, vol. 74, No. 4, pp. 1196-1212, Sep. 1989.
Banu et al., "Modulation of Hematopoietic Progenitor Development by Recombinant Human FLT3 Ligand" Blood (abstract No. 1061) 84(10):269a (Nov. 1994).
Wang et al., "The Murine stk gene Product, a Transmembrane protein Tyrosine Kinase, is a Receptor for Macrophage-Stimulating Protein" Proc. Natl. Acad. Sci. USA 92(9):3933-3937 (1995).
Remington's Pharmaceutical Sciences, Olso et al., 16th edition, Mack Publishing Co. (1980).
"Partners & Projects" Genetic Engineering News (Advertisement for U.S. Application Ser. No. 07/914,630) p. 48 (Aug. 1994).
"The Polymerase Chain Reaction" Current Protocols in Molecular Biology, Ausubel et al., Greene Publishing Associates & Wiley Interscience, Chapter 15, vol. 2:15.0.1-15.8.8 (1991).
Asami et al., "Purification and Characterization of Hepatocyte Growth Factor from Injured Liver of Carbon Tetrachloride-Treated Rats" J. Biochem. 109:8-13 (1991).
Avraham et al., "Characterization of Adhesive Interactions between Human Endothelial Cells and Megakaryocytes" J. Clin. Invest. 91:2378-2384 (Jun. 1993).
Avraham et al., "Effects of the Stem Cell Factor, c-kit Ligand, on Human Megakaryocytic Cells" Blood 79(2):365-371 (Jan. 15, 1992).
Banu et al., "Tissue Sources of Murine Megakaryocyte Potentiator: Biochemical and Immunological Studies" British Journal of Haematology 75:313-318 (1990).
Bennett et al., "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera" Journal of Biological Chemistry 266(34):23060-23067 (Dec. 5, 1991).
Bottaro et al., "Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product" Science 251:802-804 (1991).
Bruno et al., "Effect of Interleukin 6 on in vitro Human Megakaryocytopoiesis: Its Interaction with Other Cytokines" Experimental Hematology 17:1038-1043 (1989).
Burstein et al., "Megakaryocytopoiesis in the Mouse: Response to Varying Platelet Demand" Journal of Cellular Physiology 109:333-341 (1981).
Burstein et al., "Thrombocytopoiesis in Normal and Sublethally Irradiated Dogs: Response to Human Interleukin-6" Blood 80(2):420-428 (Jul. 15, 1992).
Cachianes et al., "Epstein-Barr Virus-Derived Vectors for Transient and Stable Expression of Recombinant Proteins" BioTechniques 15(2):255-259 (1993).
Chan et al., "Identification of a Competitive HGP Antagonist Encoded by an Alternative Transcript" Science 254:1382-1385 (1991).
Collins et al., "Effect of PIXY321 on Hematologic Recovery After High-Dose Cyclophosphamide (CTX), Etoposide (VP-16) and Cisplatin (CDDP) (CEP) in Women with Breast Carcinoma" Blood (Abstract No. 1447) 82:366a (1993).
Cooper et al., "Amplification and Overexpression of the met Gene in Spontaneously Transformed NIH3T3 Mouse Fibroblasts" EMBO Journal 5(10):2623-2628 (1986).
Crawford et al., "Phase I/II Trial of Recombinant Human Interleukin-6 (rhIL-6) and Granulocyte Colony Stimulating Factor (rhG-CSF) Following Ifosphamide, Carboplatin and Etoposide (ICE) Chemotherapy in Patients with Advanced Non-small Cell Lung Carcinoma (NSCLC)" Blood (Abstract No. 1454) 82:367a (1993).
de Sauvage et al., "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand" Nature 369:533-538 (Jun. 16, 1994).
Dean et al., "The Human met Oncogene is Related to the Tyrosine Kinase Oncogenes" Nature 318:385-388 (Nov. 28, 1985).
Degan et al., "Characterization of the Mouse cDNA and Gene Coding for a Hepatocyte Growth Factor-like Protein: Expression during Development" Biochemistry 30:9781-9791 (1991).
Demetri et al., "Stimulation of Thrombopoiesis by Recombinant Human Interleukin-6 (IL-6) Pre- and Post-Chemotherapy in Previously Untreated Sarcoma Patients with Normal Hematopoiesis" Blood (Abstract No. 1452) 82:367a (1993).
Dexter et al., "Growth and Differentiation in the Hemopoietic System" Ann. Rev. Cell Biol. 3:423-441 (1987).
Ebbe et al, "Megakaryocyte Maturation Rate in Thrombocytopenic Rats" Blood 32(5):787-795 (Nov. 1968).
Fay et al., "Concomitant Administration of Interleukin-6 (rhIL-6) and Leucomax (rhGM-CSF) Following Autologous Bone Marrow Transplantation-A Phase I Trial" Blood (Abstract No. 1701) 82:431a (1993).
Gaudino et al., "Ron is a Heterodimeric Tyrosine Kinase Receptor Activated by the HGF Homologue MSP" The EMBO Journal 13(15):3524-3532 (1994).
Giordano et al., "Transfer of Motogenic and Invasive Response to Scatter Factor/Hepatocyte Growth Factor by Transfection of Human met Protooncogene" Proc. Natl. Acad. Sci. USA 90:649-653 (Jan. 1993).
Giordano et al., "Tyrosine Kinase Receptor Indistinguishable from the C-Met Protein" Nature 339:155-156 (May 11, 1989).
Gohda et al., "Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure" J. Clin. Invest. 81:414-419 (1988).
Gordon et al., "Growth Factors Affecting Human Thrombocytopoiesis: Potential Agents for the Treatment of Thrombocytopenia" Blood 80(2):302-307 (Jul. 15, 1992).
Graham et al., "Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5" J. Gen. Virol. 36:59-72 (1977).
Graham et al., "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA" Virology 52:456-467 (1973).
Greenberg et al., "Characterization of a New Megakaryocytic Cell Line: The Dami Cell" Blood 72(6):1968-1977 (Dec. 1988).
Han et al., "Characterization of the DNF15S2 Locus on Human Chromosome 3: Identification of a Gene Coding for Four Kringle Domains with Homology to Hepatocyte Growth Factor" Biochemistry 30:9768-9780 (1991).
Harrison et al., "Hepatic Expression of Hepatocyte-Growth-Factor-Like/Macrophage-Stimulating Protein mRNA in Fulminant Hepatic Failure" Lancet 344:27-28 (Jul. 2, 1994).
Hartmann et al., "A Functional Domain in the Heavy Chain of Scatter Factor/Hepatocyte Growth Factor Binds the c-Met Receptor and Induces Cell Dissociation but Not Mitogenesis" Proc. Natl. Acad. Sci. USA 89:11574-11578 (Dec. 1992).
Herodin et al., "Recombinant Glycosylated Human Interleukin-6 Accelerates Peripheral Blood Platelet Count Recovery in Radiation-Induced Bone Marrow Depression in Baboons" Blood 80(3):688-695 (Aug. 1, 1992).
Hoffman, "Regulation of Megakaryocytopoiesis" Blood 74(4):1196-1212 (1989).
Igawa et al., "Hepatocyte Growth Factor is a Potent Mitogen for Cultured Rabbit Renal Tubular Epithelial Cells" Biochem. & Biophys. Res. Comm. 174(2):831-838 (Jan. 31, 1991).
Ishibashi et al., "Effect of Recombinant Granulocyte-Macrophage Colony-Stimulating Factor on Murine Thrombocytopoiesis In Vitro and In Vivo" Blood 75(7):1433-1438 (Apr. 1, 1990).
Iwama et al., "Molecular Cloning of a Novel Receptor Tyrosine Kinase Gene, STK, Derived from Enriched Hematopoietic Stem Cells" Blood 83:3160-3169 (Jun. 1, 1994).
Kaushansky et al., "Promotion of Megakaryocyte Progenitor Expansion and Differentiantion by the c-Mpl Ligand Thrombopoietin" Nature 369:568-571 (Jun. 16, 1994).
Kimura et al., "Megakaryocytopoiesis in the Rat: Response to
Avraham Hava Karsenty
Godowski Paul J.
Beth Israel Deaconess Medical Center Inc.
Conley Deirdre L.
Genentech Inc.
Gupta Anish
Marschang Diane L.
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