Methods and kits for use in preventing restenosis

Details Methods and kits for use in preventing restenosis Methods and kits for use in preventing restenosis

1999-12-02

2000-12-05

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Hydrochloric acid

A61K 3318

Patent

active

061563501

ABSTRACT:
Methods and kits are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.

REFERENCES:
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Casterella, Peter J., et al., "Prevention of Coronary Restenosis," Cardiology in Review (1999) vol. 7, No. (4):219-231.
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Johnson, G.J., et al., "The Utility of Animal Models in the Preclinical Study of Interventions to Prevent Human Coronary Artery Restenosis: Analysis and Recommendations," Thromb Haemost (1999) vol.:835-43.
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Thaulow, Erik, "Pharmacologic Effects of Calcium Channel Blockers on Restensosis," Journal of Cardiovascular Pharmacology (1999) vol. 33, (Suppl. 2):S12-S16.
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