Chemistry: analytical and immunological testing – Cancer
Patent
1996-08-27
1998-08-25
Huff, Sheela
Chemistry: analytical and immunological testing
Cancer
435 6, 435 71, 435 72, 435 723, 435 79, 435 791, 435 792, 435 793, 435 794, 435 795, 435 29, 435 30, 435296, 435810, 435975, 436501, 436523, 436161, 436162, 436177, 436178, 436507, 436508, 436810, 436813, 436514, 604 74, 604 75, 604 76, G01N 3348, G01N 3353, G01N 33567, G01N 33542, A61M 106
Patent
active
057982660
ABSTRACT:
Non-invasive methods and kits are provided for obtaining biological samples of mammary fluid or mammary fluid components by administering oxytocin or an oxytocin analogue to a mammalian patient to stimulate expression of mammary fluid. The oxytocin is preferably administered intranasally and causes myoepithelial contraction of target alveolar-ductal tissues of the breast. During or after mammary fluid expression, a biological sample is collected in the form of whole mammary fluid, whole cells or cellular components, other selected liquid or solid fractions of the mammary fluid, purified or bulk proteins, glycoproteins, peptides, nucleotides or other desired constituents of mammary fluid. Methods and kits are also provided for determining the presence or amount of a breast disease marker in biological samples of mammary fluid or mammary fluid components. Samples obtained according to the above sample collection methods are assayed to determine the presence and/or amount of a breast disease marker, for example a breast cancer marker such as CEA, HMFG, MCA, vasopressin, or cathepsin D, in the sample. Cellular samples obtained according to the above sample collection methods are also examined microscopically for cytological evidence of breast disease.
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Quay Debra L.
Quay Steven C.
Huff Sheela
K-Quay Enterprises LLC
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