Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1997-08-04
2000-06-20
Davenport, Avis M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530300, 530345, 530350, 514 2, C07K 100, A01N 3718, A61K 3800
Patent
active
06077939&
ABSTRACT:
This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal .alpha.-carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.
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Ghosh-Dastidar Pradip
Menon-Rudolph Sunitha
Wei Ziping
Davenport Avis M.
Morrison Alan J.
Ortho-McNeil Pharmaceutical , Inc.
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