Methods and kits for identifying human arylamine N-acetyltransfe

Details Methods and kits for identifying human arylamine N-acetyltransfe Methods and kits for identifying human arylamine N-acetyltransfe

1994-10-11

1996-06-18

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104

Patent

active

055276776

ABSTRACT:
The invention provides polymorphic human arylamine N-acetyltransferase (NAT) genes, more precisely a type 1 NAT gene containing the 5'-noncoding region base sequence of SEQ ID NO:1 and the coding region-containing base sequence of SEQ ID NO:2, a type 2 NAT gene containing the sequences of SEQ ID NO:3 and SEQ ID NO:4 and a type 3 NAT gene containing the sequences of SEQ ID NO:5 and SEQ ID NO:6, as well as a method of detecting these polymorphic genes and a method of diagnosing an adverse effect or effects to be caused by an amino-containing aromatic substance.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
Deguchi et al., J. Biol. Chem. 265(22), 12757-12760 (1990).
Grant et al., Nucleic Acids Res. 17(10), 3978 (1989).
Blum et al., DNA and Cell Biol. 9(3), 193-203 (1990).
Blum et al., Proc. Natl. Acad. Sci. USA 88, 5237-5241 (1991).
The Journal of Biological Chemistry, vol. 263, No. 16, pp. 7534-7538, "Arylamine N-Acetyltransferase from Chicken Liver", (1988) Ohsako et al. (1988).
The Journal of Biological Chemistry, vol. 265, No. 8, pp. 4630-4634, "Cloning and Expression of cDNAs for Polymorphic and Monomorphic Arylamine N-Acetyltransferases from Human Liver", (1990) Ohsako et al. (1990).
Biochemical and Biophysical Research Communications, vol. 177, No. 3, pp. 1252-1257, "Structure and Restriction Fragment Length Polymorphism of Genes for Human Liver Arylamine N-Acetyltransferases", (1991) Ebisawa et al.

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