Methods and kits for determining the pen polymorphism of human p

Details Methods and kits for determining the pen polymorphism of human p Methods and kits for determining the pen polymorphism of human p

1995-06-07

1999-10-26

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

530324, 536 2431, C12Q 168

Patent

active

059726016

ABSTRACT:
Isolated polynucleotide molecules and peptides encoded by these molecules can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications, relating to human platelet Pen polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from platelet mRNA, it is possible to type glycoprotein GPIIIa with regard to the Pen polymorphism, for example, in the context of diagnosing and treating clinical syndromes associated with GPIIIa-related immune responses.

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Zimrin, A.B. 1990 J.Biol. Chem vol. 265 (2): 8590-8595.
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Furihata et al., "On the Association of the Platlet-specific Alloantigen, Pen.sup.a, with Glycoprotein Illa: Evidence for Heterogeneity of Glycoprotein Illa," J. Clin. Invest. 80: 1624-1630 (Dec. 1987).
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Wang et al., "An Amino Acid Polymorphism within the RGD Binding Domain of Platelet Membrane Glycoprotein Illa is Responsible for the Formation of the Pen.sup.a /Pen.sup.b . . . " J. Clin. Invest. 90: 2038-2043 (Nov. 1992).
Zimrin et al., "The Genomic Organization of Platelet Glycoprotein Illa," J. Biol. Chem. 265: 8590-8595 (May 25, 1990).
Derwent Abstracts for Japanese patent document No. JP2300664 and U.S. patent No. 5,288,610.

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