Methods and kits for detecting ITA in a biological sample

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007930, C435S007940, C436S501000, C436S811000

Reexamination Certificate

active

07897362

ABSTRACT:
Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of capture antibodies that specifically bind ITA. Chemiluminescent immunoassays are disclosed. The methods may be practiced with the diagnostic kits of the invention.

REFERENCES:
patent: 4946958 (1990-08-01), Campbell et al.
patent: 5356817 (1994-10-01), Cole et al.
patent: 5506150 (1996-04-01), Canick et al.
patent: 5660990 (1997-08-01), Rao et al.
patent: 6127186 (2000-10-01), Pandian
patent: 6352862 (2002-03-01), Davis et al.
patent: 6500627 (2002-12-01), O'Connor et al.
patent: 6521416 (2003-02-01), Birken et al.
patent: 2002/0142305 (2002-10-01), Chin et al.
patent: 2002/0192646 (2002-12-01), Bellet et al.
patent: 2003/0157580 (2003-08-01), Hochstrasser et al.
patent: WO 98/10282 (1998-03-01), None
patent: WO 99/41584 (1999-08-01), None
patent: WO 99/56132 (1999-11-01), None
patent: WO 00/42428 (2000-07-01), None
patent: WO 00/61638 (2000-10-01), None
patent: WO 00/70094 (2000-11-01), None
Abushoufa, R.A. et al., “The Development of a sialic acid specific lectin-immunoassay for the measurement of human chorionic gonadotrophin glycoforms in serum and its application in normal and Down's syndrome pregnancies.” Clinical Endocrinology 52, 499-508 (2000).
ATCC, The Global Bioresource Center, Product Description, assecion No. PTA 1626, Aug. 21, 2007.
ATCC, The Global Bioresource Center, Product Description, assecion No. hb-12467, Aug. 21, 2007.
AMS Biotechnology (Europe) Ltd, Monoclonal Antibody to hCG, intact, Purified—E45550M, Sep. 4, 2007.
Bahado-Singh, R. et al., “A high-sensitivity alternative to ‘routine’ genetic amniocentesis: multiple urinary analytes, nuchal thickness, and age.” Am. J. Obstet. Gynecol. Jan:180(1 pt 1):169-173 (1999).
Bahado-Singh, R.O. et al., “New triple screen test for Down syndrome: combined urine analytes and serum AFP.” J. Matern. Fetal Med. May-June; 7(3):111-114 (1998).
Bahado-Singh, R.O. et al., “Comparison of urinary hyperglycosylated human chorionic gonadotropin concentration with the serum triple screen for Down syndrome detection in high-risk pregnancies.” Am. J. Obstet. Gynecol. Nov;183(5):1114-1118 (2000).
Biocompare, The Buyer's Guide for Life Scientists, Mouse Anti-hCG, intact Monoclonal Antibody, Unconjugated, Clone 820, Aug. 21, 2007.
Biocompare, The Buyer's Guide for Life Scientists, Mouse Anti-hCG, beta Monoclonal Antibody, Unconjugated, Clone 827, Aug. 21, 2007.
Birken S. et al., “Development and Characterization of Antibodies to a Nicked and Hyperglocosylated Form of hCG from a Choriocarcinoma Patient.” Endocrine, 10:(2) 137-144 Apr. 1999.
Birken et al., Imunochemical Measurement of Early Pregnancy Isoforms of HCG: Potential Applications to Fertility Research, Prenatal Diagnosis, and Cancer, Archives of Medical Research Nov.; 32:635-643 (2001).
Cole, Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites, Clinical Chemistry 43:12 2233-2243 (1997).
Cole, L.A. et al., “Combining beta-core fragment and ottal oestriol measurements to test for Down syndrome . . . ” Prenat. Diagn. Dec;17(12):1125-1133 (1997).
Cole, L.A. et al., “Hyperglycosylated hCG, a potential alternative to hCG in Down syndrome screening.” Prenat. Diagn. Sep;18(9):926-933 (1998).
Cole, L.A. et al., “Urinary screening tests for fetal Down syndrome: II. Hyperglycosylated hCG.” Prenat. Diagn. Apr;19(4):351-359 (1999).
Cole, L.A. et al., “Urinary screening tests for fetal Down syndrome: I. Fresh β-core fragment.” Prenat. Diagn. Apr;19(4):340-350 (1999).
Cole, L.A. et al., “Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen) Immunoassay: A New Basis for Gestational Down Syndrome Screening.” Clinical Chemistry 45:12 2109-2119 (1999).
Cole, L.A. et al., “Utility of Commonly Used Commercial Human Chorionic Gonadotropin Immunoassays in the Diagnosis and Management of Trophoblastid Diseases.” Clinical Chemistry Feb. 47(2):308-315 (2001).
Cuckle, H.S. et al., “Urinary multiple marker screening for Down's syndrome.” Prenat. Diagn. Aug; 15(8):745-751 (1995).
Gentaur, Anti-H: pp. 1-13, Aug. 21, 2007.
Google search define: Hydatidiform mole, Aug. 23, 2005.
Hsu, J.J. et al., “Urine free beta-hCG and total estriiol for Down syndrome screening during the second trimester in an Asian population.” Obstet. Gynecol. Jul; 94(1):107-111 (1999).
Isozaki, T. et al., “Screening for Down syndrome pregnancy using β-core fragment: prospective study.” Prenat. Diagn. May;17(5):407-413 (1997).
Kellner, L.H. et al., “Levels of urinary beta-core fragment, total oestriol, and the ratio of the two in second-trimester screening for Down syndrome.” Prenat. Diagn. Dec;17(12):1135-1141 (1997).
Krichevsky, A. et al. “Development and Characterization of a New, Highly Specific Antibody to the Human Chorionic Gonadotropin-β Fragment.” Endocrinology Mar; 128(3):1255-1264 (1991).
Krichevsky, A. et al. “The development of a panel of monoclonal antibodies to human luteinizing hormone and its application to immunological mapping and two-site assays.” Endocrine 2:551-520 (1994).
Krichevsky, A. et al., “Development, Characterization, and Application of Monoclonal Antibodies to the Native and synthetic βCOOH-Terminal Portion of Human Chorionic Gonadotropin (hCG) That Distinguishes between the Native and Desialylated Forms of hCG.” Endocrinology Mar;134(3):1139-1145 (1994).
O'Conner, J.F. et al., “Differential Urinary gonadotrophin Profiles in Early Pregnancy and Early Pregnancy Loss.” Prenat. Diagn. 18:1232-1240 (1998).
Spencer K. et al., “Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.” Prenat. Diagn. Jul;16(7):605-613 (1996).
Spencer K. et al., “First-trimester urine free beta hCG, beta core, and total oestriol in pregnancies affected by Down's syndrome: implications for first-trimester screening with nuchal translucency and serum free beta hCG.” Prenat. Diagn. Jun;17(6):525-538 (1997).
Unknown “Serum Hyperglycosylated hCG: a Potential Screening Test for Fetal Down Syndrome.” Prenat. Diagn. 19:488-490 (1999).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and kits for detecting ITA in a biological sample does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and kits for detecting ITA in a biological sample, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and kits for detecting ITA in a biological sample will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2651411

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.