Methods and kit for early detection of acute coronary...

Details Methods and kit for early detection of acute coronary... Methods and kit for early detection of acute coronary...

2011-04-19

2011-04-19

Gakh, Yelena G (Department: 1797)

Chemistry: analytical and immunological testing

Metal or metal containing

Mn, te, re, fe, ru, os, co, rh, ir, ni, pd, pt

C436S161000, C436S164000, C436S514000, C436S528000, C436S530000, C436S807000, C436S808000, C436S810000, C436S811000, C422S051000, C422S051000, C422S067000, C422S067000, C435S007400, C435S007940, C435S970000, C435S973000, C435S975000

Reexamination Certificate

active

07927880

ABSTRACT:
The invention provides methods for early diagnosis or detection of acute coronary syndrome and prediction of adverse cardiac events on the basis of elevations of catalytic iron in biological fluid of a human subject. An embodiment of the invention provides a method for early detection of acute coronary syndrome (ACS) in a human subject at the time of presentation of the chest pain. The method includes analyzing a test sample of the biological fluid for amount of catalytic iron and detecting acute coronary syndrome in the human subject.

REFERENCES:
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Pincemail J, et al. Evaluating an individual's oxidative stress: a reality for doctors, online Jan. 27, 2006. retreived from internet site: http://web.archive.org/web/20060127012846/http://www.probiox.com/de/html/documents/EvaluatingOxidativeStress—000.PDF.
Gutteridge, John M., et al. Transient iron overload with bleomycin detectable iron in the plasma of patients with adult respiratory distress syndrome, 1994, Thorax, vol. 49, pp. 707-710.
Sempos, C.T. Body iron stores and the risk of coronary heart disease, The New England journal of medicine Apr. 1994, vol. 330, No. 16, pp. 1119 and 1124, ISSN 0028-4793.

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