Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Recovery or purification
Reexamination Certificate
2005-02-08
2005-02-08
Lankford, Jr., Leon B. (Department: 1651)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Recovery or purification
C435S235100, C435S237000, C435S325000
Reexamination Certificate
active
06852522
ABSTRACT:
The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The methods of the invention are particularly attractive for growing viruses suitable for use in vaccine and pharmaceutical formulations.
REFERENCES:
patent: 4071618 (1978-01-01), Konobe et al.
patent: 4567147 (1986-01-01), Ooi et al.
patent: 4659569 (1987-04-01), Mitsuhashi et al.
patent: 5166057 (1992-11-01), Palese et al.
patent: 5766601 (1998-06-01), Palese et al.
patent: 5854037 (1998-12-01), Palese et al.
patent: 5866694 (1999-02-01), Katinger et al.
patent: 5882650 (1999-03-01), Ennis
patent: 702085 (1996-03-01), None
patent: 780475 A1 (1997-06-01), None
patent: 59-39831 (1984-03-01), None
patent: WO 9610632 (1996-04-01), None
patent: WO 9634625 (1996-11-01), None
patent: WO 9706270 (1997-02-01), None
patent: WO 9712032 (1997-04-01), None
patent: WO 9802530 (1998-01-01), None
patent: WO 9813501 (1998-04-01), None
patent: WO 9853078 (1998-11-01), None
patent: WO 9902657 (1999-01-01), None
patent: WO 9915672 (1999-04-01), None
Egorov et al., 1997, “Generation of Influenza A Transfectant Viruses Containing Deletions in the NS1 Protein”, Institute of Applied Microbiology, in Emergence and Re-emergence of Negative Strand Viruses, Tenth International Conference on Negative Strand Viruses. Sep. 21-26, Dublin. Ireland.
Aoki K et al., “Differential sensitivity of two related viruses, Newcastle disease virus and Sendai virus, to interferon in mouse Had-2 cells selective inhibition of translation of NDV mRNA.”, Arch Virol. 1996;141(10):1847-62.
Baez M et al., “Complete nucleotide sequence of the influenza A/PR/8/34 virus NS gene and comparison with the NS genes of the A/Udorn/72 and A/FPV/Rostock/34 strains”, Nucleic Acids Res. Dec. 11, 1980;8(23):5845-58.
Beatrice et al., “Immunogenicity in mice of temperature-sensitive mutants of vesicular stomatitis virus: early appearance in bronchial secretions of an interferon-like inhibitor”, J Gen Virol. 1980; 47:529-533.
Belardelli F and Gresser I, “The neglected role of type I interferon in the T-cell response: implications for its clinical use”, Immunol Today. Aug. 1996;17(8):369-72.
Buonagurio DA et al., “Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene”, Science. May 23, 1986;232(4753):980-2.
Butterfield et al., “Vaccination for fowl plague”, Am J Vet Res. Apr. 1978; 39(4):671-674.
Chen Z et al., “Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery”, EMBO J. Apr. 15, 1999;18(8):2273-83.
Crowe JE, “Immune responses of infants to infection with respiratory viruses and live attenuated respiratory virus candidate vaccines”, Vaccine. Aug. 1998; 16(14/15):1423-1432.
de la Luna S et al., “Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs”, J Virol. Apr. 1995;69(4):2427-33.
Desmyter J et al., “Defectiveness of interferon production and of rubella virus interference in a line of African green monkey kidney cells (Vero)”, J Virol. Oct. 1968;2(10):955-61.
Diaz MO et al., “Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines”, Proc Natl Acad Sci U S A. Jul. 1988;85(14):5259-63.
Dulbecco et al., 1988, “Multiplication and Genetics of Animal Viruses”, Virology Ch.48.
Durbin JE et al., “Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease”, Cell. Feb. 9, 1996;84(3):443-50.
Egorov A et al., “Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells”, J Virol. Aug. 1998;72(8):6437-41.
Egorov AY et al., “Generation of influenza A transfectant viruses containing deletions of the carboxyl-terminal part of the NS1 protein”, inEmergence and Re-emergence of Negative Strand Viruses, Tenth International Conference on Negative Strand Viruses. 1997, Dublin, Ireland. Abstract No. 108, p. 104.
Egorov Alu et al., “[The NS gene—a possible determinant of apathogenicity of a cold-adapted donor of attenuation A /Leningrad/134/47/57 and its reassortants]”, Vopr Virusol. Sep.-Oct. 1994;39(5):201-5. Russian.
Enami M and Palese P, “High-efficiency formation of influenza virus transfectants”, J Virol. May 1991;65(5):2711-3.
Enami M et al., “An influenza virus containing nine different RNA segments”, Virology. Nov. 1991;185(1):291-8.
Enami K et al., “Influenza virus NS1 protein stimulates translation of the M1 protein”, J Virol. Mar. 1994;68(3):1432-7.
Ferner et al. 1974.The Biology of Animal Viruses2ndEd. New York: Academic Press. 42-43.
Fodor E et al., “Attenuation of influenza A virus mRNA levels by promoter mutations”, J Virol. Aug. 1998;72(8):6283-90.
Fortes P et al., “Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport”, EMBO J. Feb. 1, 1994;13(3):704-12.
Garcia-Sastre A et al., “The role of interferon in influenza virus tissue tropism”, J Virol. Nov. 1998;72(11):8550-8.
Garcia-Sastre A et al., “Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems”, Virology. Dec. 20, 1998;252(2):324-30.
Goodpasture et al. “The cultivation of vaccine and other viruses in the chorioallantoic membrane of chick embryos”, Science. 1934; 74(1919):371-372.
Haller O et al., “Host gene influences sensitivity to interferon action selectively for influenza virus”, Nature. Feb. 14, 1980;283(5748):660-2.
Haller O et al., “Genetic resistance to influenza virus in wild mice”, Curr Top Microbiol Immunol. 1986;127:331-7.
Haller O., “Inborn resistance of ice to orthomyoviruses”, Curr Top Microbiol Immunol. 1981;92:25-52.
Hatada E et al., “Binding of influenza A virus NS1 protein to dsRNA in vitro”, J Gen Virol. Dec. 1992;73 ( Pt 12):3325-9.
Krug, 1995, “Chapter 8. Unique Functions of the NS1 Protein” inTextbook of Influenza, Nicholson et al. (eds.), pp. 82-92.
Krug and Soeiro, 1975, “Studies on the intranuclear localization of influenza virus-specific proteins”, Virology 64: 378-87.
Li X and Palese P, “Mutational analysis of the promoter required for influenza virus virion RNA synthesis”, J Virol. Jul. 1992;66(7):4331-8.
Li X and Palese P, “Characterization of the polyadenylation signal of influenza virus RNA”, J Virol. Feb. 1994;68(2):1245-9.
Lu Y et al., “Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation intiation factor”, Virology. Dec. 1, 1995;214(1):222-8.
Lu Y et al., “The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing”, Genes Dev. Aug. 1, 1994;8(15):1817-28.
Luo GX et al., “The polyadenylation signal of influenza virus RNA involves a stretch of uridines followed by the RNA duplex of the panhandle structure”, J Virol. Jun. 1991;65(6):2861-7.
Luyties W et al., “Amplification, expression, and packaging of foreign gene by influenza virus”, Cell. Dec. 22, 1989;59(6):1107-13.
Maramorosh, K and Koprowski, H. 1967.Methods in Virologyvol. 1. Ch 6. New York: Academic Press. 178-216.
Marion RM et al., “The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation”, Nucleic Acids Res. Nov. 1, 1997;25(21):4271-7.
Marion RM et al., “The N-terminal half of in
Garcia-Sastre Adolfo
O'Neil Robert
Palese Peter
Jones Day
Lankford , Jr. Leon B.
Mount Sinai School of Medicine of New York University
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