Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2006-11-07
2006-11-07
Gambel, Phillip (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C435S325000, C435S326000, C435S328000, C435S069100, C435S069600, C435S070100, C435S070210
Reexamination Certificate
active
07132281
ABSTRACT:
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
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Chuang et
Corvalan Jose Ramon
Davis C. Geoffrey
Gilman Steven Christopher
Hanke Jeffrey Herbert
Hanson Douglas Charles
Amgen Fremont Inc.
Gambel Phillip
Gunnison Jane T.
Ouspenski Ilia
Pfizer Inc.
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