Methods and gel compositions for encapsulating living cells...

Details Methods and gel compositions for encapsulating living cells... Methods and gel compositions for encapsulating living cells...

2007-02-06

2007-02-06

Lankford, Jr., Leon B (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S325000, C435S395000, C435S287200, C527S301000, C527S204000, C436S518000

Reexamination Certificate

active

10398725

ABSTRACT:
A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional hydrogel prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions. An additional bidentate crosslinking agent may be included. The product of such method may be a bioreactor or an assay device having a plurality or different biologics encapsulated at predetermined locations in a substrate.

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