Methods and formulations for preventing progression of neuropath

Details Methods and formulations for preventing progression of neuropath Methods and formulations for preventing progression of neuropath

1997-11-07

1999-04-06

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530300, 530324, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

058918493

ABSTRACT:
A method of preventing progression of neuropathic pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking compound which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention.

REFERENCES:
patent: 5587454 (1996-12-01), Justice et al.
patent: 5795864 (1998-08-01), Amstutz et al.

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