Methods and dosage forms for the treatment of human cancers

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

08039025

ABSTRACT:
Methods for the treatment of human cancers, daily dosage forms for cancer patients, and methods of formulating the dosage forms are provided wherein the daily dosage form contains from about 10-6,000 mg of each of β-sitosterol, isovanillin, and linolenic acid. Preferably, the dosage forms are formulated by first creating an aqueous decoction ofArum palaestinumBoiss, followed by fortification of the decoction with additional quantities of β-sitosterol, isovanillin, and linolenic acid.

REFERENCES:
patent: 3332969 (1967-07-01), Hutt, Jr. et al.
patent: 5002767 (1991-03-01), Massë
patent: 5118671 (1992-06-01), Bombardelli et al.
patent: 5486510 (1996-01-01), Bouic et al.
patent: 6030622 (2000-02-01), Shehadeh
patent: 6139897 (2000-10-01), Goto et al.
patent: 6413571 (2002-07-01), Liu
patent: 6491952 (2002-12-01), Sjoberg
patent: 7351739 (2008-04-01), Ho et al.
patent: 2006/0034944 (2006-02-01), Rushlow et al.
patent: 2006/0104940 (2006-05-01), Heinrichs et al.
patent: 2007/0142652 (2007-06-01), Arumughan et al.
patent: 2007/0183993 (2007-08-01), Binder et al.
patent: 2008/0102111 (2008-05-01), Imanaka
patent: 2008/0221221 (2008-09-01), Zhou et al.
patent: 2009/0304827 (2009-12-01), Kim
patent: 2011/0098362 (2011-04-01), Zhou et al.
patent: 5213586 (1987-09-01), None
patent: 1724555 (2006-01-01), None
patent: 0985411 (2000-03-01), None
patent: 2009029015 (2009-03-01), None
patent: WO 0064921 (2000-11-01), None
patent: WO 02079219 (2002-10-01), None
patent: WO 2007/073583 (2007-07-01), None
Xu et al. Zhongguo Zhong Yao Za Zhi. Apr. 2009. vol. 34, No. 8, pp. 990-993.
Awad, A. B. et al. “β-Sitosterol Activates Fas Signaling in Human Breast Cancer Cells.” Phytomedicine 14 (2007) 747-754.
Baskar, Albert A. et al. “Chemopreventive Potential of β-Sitosterol in Experimental Colon Cancer Model—an in vitro and in vivo Study.” BMC Complementary and Alternative Medicine 10:24 (2010) 1-10. Available online at http://www.biomedcentral.com/1472-6882/10/24.
El-Desouky, S. K. et al. “Piperazirum, a Novel Bioactive Alkaloid fromArum palaestinumBoiss.” Tetrahedron Letters 48 (2007) 4015-4017. Available online at www.sciencedirect.com.
Said, O. et al. “Ethnopharmacological Aurvey of Medicinal Herbs in Israel, the Golen Heights and the West Bank Region.” Journal of Ethnopharmacology 83 (2002) 251-265.
Ali-Shtayeh, Mohammed S. Et al. “Traditional Knowledge of Wild Edible Plants Used in Palestine (Northern West Bank): A Comparative Study.” Journal of Ethnobiology and Ethnomedicine 4.13 (2008). Available online at http://www.ethnobiomed.com/content/4/1/13.
Anwar, Farooq et al. “Fatty Acid, Tocopherol and Sterol Compositions of Canadian Prairie Fruit Seed Lipids.” J Am Oil Chem Soc 85 (2008): 953-959. First page only.
Awad, A. B. et al. “Beta-Sitosterol Enhances Tamoxifen Effectiveness on Breast Cancer Cells by Affecting Ceramide Metabolism.” Mol Nutr Food Res 52(4) (2008): 419-26. Abstract only.
Awad, A. B. et al. “Beta-Sitosterol Inhibits Ht-29 Human Colon Cancer Cell Growth and Alters Membrane Lipids.” Anticancer Res. 16(5A) (1996): 2797-804. Abstract only.
Awad, A. B. et al. “Inhibition of Growth and Stimulation of Apoptosis by Beta-Sitosterol Treatment of MDA-MB-231 Human Breast Cancer Cells in Culture.” Int.J.Mol.Med. 5(5) (2000): 541-545. (Abstract only).
Awad, Atif B. Et al. “Phytosterols as Anticancer Dietary Components: Evidence and Mechanism of Action.” Journal of Nutrition 130 (2000): 2127-2130. Downloaded from jn.nutrition.org on Jan. 7, 2010.
Behrman, E.J. et al. “Cholesterol and Plants.” Journal of Chemical Education. Unknown volume and year. www.JCE.DivCHED.org, 2011.
Berges, R. R. et al. “Randomised, Placebo-Controlled Double-Blind Clinical Trial of β-Sitosterol in Patients with Benign Prostatic Hyperplasia.” The Lancet 345 (Jun. 17, 1995): 1529-1532.
Berry, C.P. et al. “Analysis of Free and Esterified Sterols in Wheat Flour and Semolina.” 534d Annual Meeting, Cooperative Investigation between North Dakota Agricultural Experiment Station and Crops Research Division (Nov. 1968): 616-626.
Bradford, P.G. et al. “Phytosterols as Anticancer Compounds.” Mol Nutr Food Res. 51(2) (2007): 161-70. Abstract only.
Committee on Comparative Toxicity of Naturally Occurring Carcinogens, National Research Council. “Carcinogens and Anticarcinogens in the Human Diet: A Comparison of Naturally Occurring and Synthetic Substances.” 1996. Abstract only. Available online at http://www.nap.edu/catalog.php?record—id=5150.
Das, U. N. “Gamma-linolenic Acid, Arachidonic Acid, and Eicosapentaenoic Acid as Potential Anticancer Drugs.” Nutrition 6(6) (1990): 429-34. Abstract only.
Das, U. N. et al. “Local Application of Gamma-linolenic Acid in the Treatment of Human Gliomas.” Cancer Lett. 94(2) (1995): 147-55. Abstract only.
El-Desouky, S. K. et al. “A New Pyrrole Alkaloid Isolated fromArum palaestinumBoiss. And its Biological Activities.” Arch.Pharm.Res. 30.8 (2007): 927-931.
Jacam Chemicals, LLC (sponsor). “Acute Oral Toxicity Up and Down Procedure in Rats.” Eurofins Product Safety Laboratories, Study No. 24321. Apr. 14, 2008.
Jaradat, Dr. Nidal A. “Medical Plants Utilized in Palestinian Folk Medicine for Treatment of Diabetes Mellitus and Cardiac Diseases.” J. Al-Aqsa Unv. 9 (2005): 1-28.
Jiang, W.G. et al. Inhibition of Hepatocyte Growth Factor—Induced Motility and In vitro Invasion of Human Colon Cancer Cells by Gamma-Linolenic Acid. British Jounral of Cancer 71(1995): 744-752.
Jiang, Wen G. et al. “Regulation of the Expression fo E-Cadherin on Human Cancer Cells by γ-Linolenic Acid (GLA).” Cancer Research 55 (Nov. 1, 1995): 5043-5048.
Kapetanovic, Radomir et al. “Sterol Composition of the Adriatic Sea AlgaeUltra lactuca, Codium dichotomum, Cystoseira adriatica and Fucus virsoides..” J.SerbChem.Soc. 70 (12) (2005): 1395-1400.
Kuo, Reen-Yen et al. “Chemical Constituents and Their Pharmacological Activities from Formosan Annonaceous Plants.” The Chinese Pharmaceutical Journal 54 (2002): 155-173.
Kuksis, A. et al. “Composition of Molecular Distillates of Corn Oil: Isolation and Identification of Sterol Esters.” J. Lipid Research. 1 (1960): 311-320.
Peters, Wilbert H.M. et al. “Chapter 31—Antigenotoxins and Cancer.” The Cancer Handbook. Ed. Lynn MacTaggart. Bloomingdale, IL: Vital Health Publishing, 1997. 421-434.
Saad, Bashar et al. “Tradition and Perspectives of Arab Herbal Medicine: A Review.” eCAM (2005): 1-5. Downloaded from http://ecam.oxfordjournals.org on Mar. 15, 2010.
Shukla, R. S. et al. “Steroidal Composition of the Root Extract ofOrthosiphon tomentosus, Benth (Lamiaceae) Used in Tribal Medicine.” Journal of Pharmacy Research 2 (2009): 1137-1138.
Strum, Stephen B. “Beta-Sitosterol and the Aging Prostate Gland.” LE Magazine (Jun. 2005). Available online at http://www.lef.org.
Sugimura, Takashi et al. “Chapter 28—Dietary Genotoxins and Cancer.” The Cancer Handbook. Ed. Lynn MacTaggart. Bloomingdale, IL: Vital Health Publishing, 1997. 389-397.
Yan, Yu-Qian. “Vanillin Derivative 6-bromine-5-hydroxy-4-methozybenzaldehyde-Elicited Apoptosis and G2M Arrest of Jurkat Cells Proceeds Concurrently with DNA-PKcs Cleavage and Akt Inactivation.” International Jounral of Oncology 29 (2006): 1167-1172.
Vachalkova, A. et al. “Taraxasterol and β-Sitosterol: New Naturally Compounds with Chemoprotective/chemopreventive Effects.” Neoplasma 51 (2004): 407-14. Abstract only.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and dosage forms for the treatment of human cancers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and dosage forms for the treatment of human cancers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and dosage forms for the treatment of human cancers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4287205

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.