Methods and devices for the separation of plasma or serum from w

Details Methods and devices for the separation of plasma or serum from w Methods and devices for the separation of plasma or serum from w

1989-04-07

1990-06-12

Jones, W. Gary

Liquid purification or separation

Processes

Making an insoluble substance or accreting suspended...

210295, 210314, 210335, 2105101, 210730, 210732, 210806, 422101, 435 2, 436177, B01D 3700, B01D 3914

Patent

active

049330926

ABSTRACT:
A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum or plasma from the matrix.
According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix is the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix.

REFERENCES:
patent: 3888629 (1975-06-01), Bagghawe
patent: 3902964 (1975-09-01), Greenspan
patent: 4464254 (1984-08-01), Dojki et al.
patent: 4477575 (1984-10-01), Vogel et al.
patent: 4594327 (1986-06-01), Zuk
patent: 4753776 (1988-06-01), Hillman et al.
patent: 4820644 (1989-04-01), Schafer et al.

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