Methods and devices for the delivery of monomeric proteins

Details Methods and devices for the delivery of monomeric proteins Methods and devices for the delivery of monomeric proteins

1996-11-12

1998-09-15

Buiz, Michael Powell

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

604 85, 210638, 210651, 21050021, 530304, 514 3, A61M 3100

Patent

active

058073159

ABSTRACT:
Methods and devices for dissociating multimeric proteins and their delivery to patients, along with resultant compositions, are provided. A monomeric protein delivery device is also provided, comprising a supply of a multimeric protein 4, complex, comprising multimeric protein and an aggregating agent; a flow path having a subcutaneous exit 8, fluidly coupling the multimeric protein supply to the exit; a porous surface assembly situated along the flow path comprising a porous surface 10; and an aggregating agent binding partner carried by the surface 12; whereby the aggregating agent of the multimeric protein complex passing along the surface is bound to the binding partner on the surface to create a monomeric protein flow through the subcutaneous exit.

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