Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-07-04
2006-07-04
Goldberg, Jeanine A. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
07070932
ABSTRACT:
Methods and devices for detecting deposition unit misalignment, e.g., printhead misalignment, of an in situ polymeric, e.g., a nucleic acid, array synthesis device are provided. In accordance with the subject methods, at least one test probe feature is synthesized on a substrate using an in situ polymeric array, e.g., nucleic acid array or protein array, synthesis device. The at least one test probe feature is then contacted with at least two different distinguishably labeled targets, e.g., target nucleic acids. The binding of the targets to the at least one test probe feature is then evaluated to detect any misalignment, e.g., deposition unit or pulse jet misalignments, of the synthesis device. Also provided are substrates having at least one test probe feature and at least one polymeric array, as well as methods of using the substrates in array assays. Also included are kits for use in practicing the subject methods.
REFERENCES:
patent: 6232072 (2001-05-01), Fisher
patent: 6284465 (2001-09-01), Wolber
patent: 6300137 (2001-10-01), Earhart et al.
patent: 2003/0148539 (2003-08-01), van Dam et al.
Khan et al. (Genomics, vol. 81, pp. 157-165, Feb. 20, 2003).
Amorese Douglas A.
Kronick Mel N.
Leproust Eric M.
Agilent Technologie,s Inc.
Goldberg Jeanine A.
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