Methods and devices for characterizing particles in clear...

Details Methods and devices for characterizing particles in clear... Methods and devices for characterizing particles in clear...

2011-07-05

2011-07-05

Porta, David P (Department: 2884)

Radiant energy

Luminophor irradiation

Reexamination Certificate

active

07973294

ABSTRACT:
The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.

REFERENCES:
patent: 4940332 (1990-07-01), Miwa et al.
patent: 6759662 (2004-07-01), Li
patent: 6794659 (2004-09-01), Barbieri et al.
patent: 7528384 (2009-05-01), Gratton et al.
patent: 2003/0092058 (2003-05-01), Spaulding
patent: 2005/0264817 (2005-12-01), Havard et al.
patent: 2006/0114553 (2006-06-01), Laudo
patent: 2006/0129327 (2006-06-01), Kim et al.
Berland et al. (Feb. 1995) “Two Photon Fluorescence Correlation Spectroscopy: Method and Application to the Intracellular Environment,”Biophys. J. 68:694-701.
Chen et al. (Jul. 1999) “The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy,”Biophys. J. 77(1):553-567.
Deller et al. (1999) “Topics in Statistical Pattern Recognition,” In;Discrete-Time Processing of Speech Signals, IEEE Press, pp. 55-73.
Duda et al. (2001) “Pattern Recognition Systems.” In;Pattern Classification, Wiley-Interscience, pp. 9-13.
Elson et al. (1974) “Fluorescence Correlation Spectroscopy. I. Conceptual Basis and Theory,”Biopoloymers13:1-27.
Kask et al. (Nov. 23, 1999) “Fluorescence-Intensity Distribution Analysis and Its Application in Bimolecular Detection Technology,”Proc. Natl. Acad. Sci. USA96:13756-13761.
Magde et al. (1974) “Fluorescence Correlation Spectroscopy. II. AN Experimental Realization,”Biopolymers13:29-61.
Qing et al. (Jun. 1, 2003) “Convective-diffusion-based fluorescence correlation spectroscopy for detection of a trace amount ofE. coliin water,” App. Optics 42:2987-2994.
Tahari et al. (Feb. 2005) “Fluorescence Correlation Spectroscopy in Turbid Media”, Presented at the Biophysical Society Meeting, Feb. 16, 2005, Long Beach, California.
Tahari et al. (Feb. 2001) “Fluctuation Correlation Spectroscopy in Turbid Media: Detection of Somatic Cells and Bacteria in Body Fluids”, Presented at the Biophysical Society Meeting, Feb. 2001, Boston, Massachusetts.
Tahari et al. (Feb. 2002) “The Photon Counting Histogram in Turbid Media”, Presented at the Biophysical Society Meeting, Feb. 2002, San Francisco, California.
Tahari et al. (Feb. 2004) “Fluorescence Correlation Spectroscopy in Turbid Media”, Presented at the Biophysical Society Meeting, Feb. 18, 2004, Baltimore, Maryland.
Tahari et al. (2002) “The Photon Counting Histogram in Turbid Media: Detection of Somatic Cells and Bacteria in Body Fluids,”Biophys. J.(Annual Meeting Abstracts) 82(1):431.
Tahari et al. (2001) “Fluctuation Correlation Spectroscopy (FCS) in Turbid Media: Detection of Somatic Cells and Bacteria in Body Fluids,”Biophys. J.(Annual Meeting Abstracts) 80(1):164.
Tahari et al. (2004) “Fluorescence Correlation Spectroscopy in Turbid Media: Ultrasensitive Detection of Bacteria, Viruses and Protein Aggregates” Website posting Aug. 2004.
Webb, W.W. (Aug. 20, 2001) “Fluorescence Correlation Spectroscopy: Inception, Biophysical Experimentations and Prospectus,”Appl. Opt. 40:3969-3983.
Search report corresponding to international application No. PCT/US06/04696, mailed Dec. 4, 2006.

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