Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-07-28
2000-04-18
Brusca, John S.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435455, 4353201, 435325, C12N 1585, C12N 1512, C12N 1563, C12N 516
Patent
active
060514019
ABSTRACT:
The invention teaches methods, constructs and host cells for the effective expression of a desired protein in mammalian cell culture. In particular, the efficient expression of human GGF2 is taught.
REFERENCES:
patent: 4533637 (1985-08-01), Yamane et al.
patent: 4560655 (1985-12-01), Baker
patent: 4757005 (1988-07-01), Chan
patent: 4767704 (1988-08-01), Cleveland et al.
patent: 4816401 (1989-03-01), Taupier et al.
patent: 5024947 (1991-06-01), Inlow et al.
patent: 5081035 (1992-01-01), Halberstadt et al.
patent: 5122469 (1992-06-01), Mather et al.
patent: 5135866 (1992-08-01), Heifetz et al.
patent: 5143842 (1992-09-01), Ham et al.
patent: 5153131 (1992-10-01), Wolf et al.
patent: 5530109 (1996-06-01), Goodearl et al.
patent: 5612213 (1997-03-01), Chan
patent: 5631159 (1997-05-01), Marshall et al.
patent: 5854021 (1998-12-01), Cho et al.
Lee, Chong-Chou et al.: "Human alpha2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript.", Proc. Nat'l. Acad. Sci. USA, vol. 84, Jul. 1987 (1987-07), pp. 4403-7.
Nie, Z.:"Fetuin: its enigmatic property of growth promotion." American Journal of Physiology, vol. 32, No. 3, Sep. 1992 (1992-09), pp. C551-C562.
Gaillard, D., et al.: "Fetuin modulates growth and differentiation of Ob17 preadipose cells in serum-free hormone-supplemented medium." Biochimica et Biophysica Acta, vol. 846, 1985, pp. 185-191.
Gene Structure and Expression, 2.sup.nd Edition, J.D. Hawkins (Cambridge University Press, London, 1991).
Hedlund and Miller, "A Serum-Free Defined Medium Capable of Supporting Growth of Four Established Human Prostatic Carcinoma Cell Lines", The Prostate 24:221-228 (1994).
Dziegielewska et al., "Alpha-2-HS-glycoprotein is Expressed at High Concentration in Human Fetal Plasma and Cerebrospinal Fluid", Fetal Diagn. Ther. 1993; 8:22-27.
Jahnen-Dechent et al., "Posttranslational processing of human alpha-2-HS-glycoprotein (human fetuin)" Eur. J. Biochem. 226:59-69 (1994).
Yoshida et al., "Cystatin-like Domain of Mouse Countertrypsin, a Member of Mammalian Fetuin Family, is Responsible for the Inhibition of Trypsin" Biochemistry and Molecular Biology International 39(5):1023-1028 (Aug. 1996).
Demetriou et al., "Fetuin/alpha-2-HS-glycoprotein is a Transforming Growth Factor-B Type II Receptor Mimic and Cytokine Antagonist", J. Bio. Chem. 271(22):12755-12761 (1996).
Ohnishi et al., "Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor", Eur. J. Biochem. 243:753-761 (1997).
Chan Sham Yuen
Cheng Shu-Lan
Tran Van-Mai
Bayer Corporation
Brusca John S.
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