Methods and compounds for the stereoselective enrichment of olig

Details Methods and compounds for the stereoselective enrichment of olig Methods and compounds for the stereoselective enrichment of olig

1995-05-23

1998-05-12

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2671, 536 2672, 536 2674, 536 268, 536 253, 536 2533, 536 2534, C07H 1920

Patent

active

057506744

ABSTRACT:
The present invention provides new mononucleotide synthons useful in the synthesis of oligonucleotides having from one to all P-chiral centers that are predominantly and independently in the R or S configuration. The invention also provides methods of synthesizing these synthons, methods of synthesizing oligonucleotides having from one to all P-chiral centers predominantly and independently in the R or S configuration, and such oligonucleotides. Oligonucleotides synthesized with the novel synthons are useful for modulating nucleic acid expression, both in vitro and in vivo, as well as in traditional hybridization assays.

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