Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-02-18
1996-05-28
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540364, C07D47104, C07D41304, C07B 4304
Patent
active
055213073
ABSTRACT:
A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.
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Jackson, et al., Synthesis of Carbacephem Antibiotics: Synthesis via Dieckmann Reaction Using Phenylesters to Direct the Regioselectivity of the Cyclization, 31 Tet. Letters 6317 (1990).
Fisher Jack W.
Hatfield Lowell D.
Hoying Richard C.
Ray James E.
Berch Mark L.
Eli Lilly and Company
Plant Thomas G.
Sales James J.
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