Methods and compounds for promoting vessel regression

Details Methods and compounds for promoting vessel regression Methods and compounds for promoting vessel regression

2011-03-01

2011-03-01

Li, Ruixiang (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100

Reexamination Certificate

active

07897581

ABSTRACT:
The present invention relates, at least in part, to methods and compositions for treating and diagnosing disorders associated with neovascularization, and methods for identifying targets and compositions used in treating and diagnosing such disorders.

REFERENCES:
patent: 6692925 (2004-02-01), Miyazono et al.
patent: 2003/0152926 (2003-08-01), Murray et al.
patent: 2008/0175844 (2008-07-01), Grinberg et al.
Alexander et al., “Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas” J. Clin. Endocrinol. Metab. 81:783-790 (1996).
Bischoff et al., “Scanning electron microscopic studies of the hyaloid vascular system in newborn mice exposed to O2 and CO2” Graefes Arch. Clin. Exp. Ophthalmol. 220(6):257-263 (1983).
Brant et al., “Ocular manifestations in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)” Am. J. Ophthalmol. 107:642-646 (1989).
Chang et al., “Corneal neovascularization” Curr. Opin. Ophthalmol. 12:242-249 (2001).
Chang et al., “Functional characterization of neostatins, the MMP-derived, enzymatic cleavage products of type XVIII collagen” FEBS Lett. 579:3601-3606 (2005).
Coffin et al., “ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor” Mod. Pathol. 14:569-576 (2001).
Dawson et al., “Pigment epithelium-derived factor: a potent inhibitor of angiogenesis” Science 285:245-248 (1999).
Diez-Roux et al.,“ Macrophages induce apoptosis in normal cells in vivo” Development 124(18):3633-3638 (1997).
Feeney et al., “Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression” Invest. Ophthalmol. Vis. Sci. 44 (2):839-847 (2003).
Felton et al., “Vitreous inhibition of tumor neovascularization” Arch. Ophthalmol. 97(9):1710-1713 (1979).
Feng et al., “Specificity and versatility in TGF-beta signaling through Smads” Annu. Rev. Cell. Dev. Biol. 659-693 (2005).
Gabison et al., “Anti-angiogenic role of angiostatin during corneal wound healing” Exp. Eye. Res. 78:579-589 (2004).
GenBank Accession No. NM—000020.1.
GenBank Accession No. NP—000011.1.
Goumans et al., “Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice” Int. J. Dev. Biol. 44:253-265 (2000).
Goumans et al., “Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors” EMBO J. 21:1743-1753 (2002).
Goumans et al., “Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways” Trends. Cardiovasc. Med. 13:301-307 (2003).
Ito et al., “Regression of the hyaloid vessels and pupillary membrane of the mouse” Anat. Embryol. (Berl). 200(4):403-411 (1999).
Jack, “Regression of the hyaloid vascular system. An ultrastructural analysis” Am. J. Ophthalmol. 74 (2):261-272 (1972).
Johnson et al., “Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2” Nat. Genet. 13:189-195 (1996).
Lamouille et al., “Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis” Blood 100:4495-4501 (2002).
Lang et al., “Macrophages are required for cell death and tissue remodeling in the developing mouse eye” Cell 74 (3):453-462 (1993).
Lang et al., “Apoptosis during macrophage-dependent ocular tissue remodeling” Development 120(12):3395-3403 (1994).
Latker et al., “Regression of the tunica vasculosa lentis in the postnatal rat” Invest. Ophthalmol. Vis. Sci. 21(5):689-699 (1981).
Lebrin et al., “TGF-beta receptor function in the endothelium” Cardiovasc. Res. 65:599-608 (2005).
Lebrin et al., “Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction.” EMBO J. 23:4018-4028 (2004).
Lutty et al., “Vitreous: an inhibitor of retinal extract-induced neovascularization” Invest. Ophthalmol. Vis. Sci. 24 (1):52-56 (1983).
Lutty et al., “Heterogeneity in localization of isoforms of TGF-beta in human retina, vitreous, and choroid” Invest. Ophthalmol. Vis. Sci. 34 (3):477-487 (1993).
Mahmoud et al., “Intraoperative choroidal hemorrhage in the Osler-Rendu-Weber syndrome” Am. J. Ophthalmol. 133:282-284 (2002).
Mann The Development of the Human Eye. pp. 201-232. Grune & Stratton Inc: New York (1964).
McAllister et al., “Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1” Nat. Genet. 8:345-351 (1994).
McMenamin et al., “Characterization of the macrophages associated with the tunica vasculosa lentis of the rat eye” Invest. Ophthalmol. Vis Sci. 43 (7):2076-2082 (2002).
Meeson et al., “A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis” Development 122(12):3929-3838 (1996).
Mitchell et al., “Regression of vessels in the tunica vasculosa lentis is initiated by coordinated endothelial apoptosis: a role for vascular endothelial growth factor as a survival factor for endothelium” Dev. Dyn. 213(3):322-333 (1998).
Murthy et al., “Corneal transduction to inhibit angiogenesis and graft failure” Invest. Ophthalmol. Vis. Sci. 44:1837-1842 (2003).
Oh et al., “Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis” Proc Natl Acad Sci USA 97:2626-2631 (2000).
Panchenko et al., “Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels” Am. J. Physiol. 270:L547-L558 (1996).
Pepper, “Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity” Cytokine Growth Factor. Rev. 8:21-43 (1997).
Preis et al., “Inhibition of neovascularization by an extract derived from vitreous” Am. J. Ophthalmol. 84(3):323-328 (1977).
Pulford et al., “Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1” Blood 89:1394-1404 (1997).
Ramesh et al., “Immunolocalisation of opticin in the human eye” Br. J. Ophthalmol. 88(5):697-702 (2004).
Roman et al., “Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels” Development 129:3009-3019 (2002).
Sadahira et al., “Bone marrow involvement in NPM-ALK-positive lymphoma: report of two cases” Pathol. Res. Pract. 195:657-661 (1999).
Seki et al., “Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling” Circ. Res. 93:682-689 (2003).
Smith, “Systematic evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods” 45-63 Sunders (2002).
Srinivasan et al., “A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2” Hum. Mol. Genet. 12:473-482 (2003).
Taylor et al., “Partial purification of a 5.7K glycoprotein from bovine vitreous which inhibits both angiogenesis and collagenase activity” Biochem. Biophys. Res. Commun. 133 (3):911-916 (1985).
ten Dijke et al., “Characterization of type I receptors for transforming growth factor-beta and activin” Science 264:101-104 (1994).
Urness et al., “Arteriovenous malformations in mice lacking activin receptor-like kinase-1” Nat. Genet. 26:328-331 (2000).
Vase et al., “Ocular lesions in hereditary haemorrhagic telangiectasia” Acta. Ophthalmol. Copen. 57:1084-1090 (1979).
Zhu et al., “Effect of human vitreous and hyalocyte-derived factors on vascular

Affiliated with

Also associated with

Rating

Methods and compounds for promoting vessel regression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compounds for promoting vessel regression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compounds for promoting vessel regression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2744006