Methods and compounds for inhibiting β-amyloid peptide...

Details Methods and compounds for inhibiting β-amyloid peptide... Methods and compounds for inhibiting β-amyloid peptide...

2005-05-03

2005-05-03

Killos, Paul J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S041000, C560S168000, C562S455000, C562S437000, C562S561000, C564S152000, C564S154000, C564S155000, C514S542000, C514S563000, C514S616000

Reexamination Certificate

active

06888022

ABSTRACT:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

REFERENCES:
patent: 4410520 (1983-10-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 5015639 (1991-05-01), Berger et al.
patent: 5206235 (1993-04-01), Fisher et al.
patent: 5247080 (1993-09-01), Berger et al.
patent: 5486541 (1996-01-01), Sterling et al.
patent: 5502048 (1996-03-01), Chapdelaire et al.
patent: 5519061 (1996-05-01), Youdim et al.
patent: 5532415 (1996-07-01), Youdim et al.
patent: 5656626 (1997-08-01), Chapdelaine et al.
patent: 5672598 (1997-09-01), De et al.
patent: 0 652 009 (1995-05-01), None
patent: 0 732 399 (1996-09-01), None
patent: 0 778 266 (1997-06-01), None
patent: 210647 (1994-07-01), None
patent: 9509838 (1995-04-01), None
patent: 9513084 (1995-05-01), None
patent: 9620725 (1996-07-01), None
patent: 9620949 (1996-07-01), None
patent: 9622966 (1996-08-01), None
patent: 9639194 (1996-12-01), None
patent: 9730072 (1997-08-01), None
Kenneth L. Kirk et al JACS 94(23) 1972 8142-7.*
Chem Abst 91: 103974 (Seikatsu Kagaku (1979), 21(1) 79-85.*
Adams, et al. “Potent and Selective Inhibitors of the Proteasome: Dipeptidyl Boronic Acids.”Biorg. and Med. Chem. Lets. 8:333-338 (1998).
Cordell, “β-Amyloid Formation as a Potential Therapeutic Target for Alzheimer's Disease.”Annu. Rev. Pharmacol. Toxicol. 34:69-89 (1994).
Lum, et al. “Selective Inhibition of the Chymotrypsin-like Activity of the 20S Proteasome by 5-Methoxy-1-Indanone Dipeptide Benzamides.”Biorg. and Med.Chem. Lets. 8:209-214 (1998).
Papadopoulos, et al. “Anodic Oxidation of N-Acyl and N-Alkoxycarbonyl Dipeptide Esters as a Key Step for the Formation of Chiral Heterocyclic Synthetic Building Blocks.”Tetrahedron, 47(4/5):563-572 (1991).
Smith, et al. “β-APP Processing as a Therapeutic Target for Alzheimer's Disease.”Current Pharmaceutical Design, 3439-445 (1997).
Waldmann, et al. “Selective Enzymatic Removal of Protecting Groups: The Phenylacetamide as Amino Protecting Group in Phosphopeptide Synthesis.”Tetrahedron Letters, 37(48):8725-8728 (1996).
Wolfe, et al. “A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity.”J. Med. Chem., 41:6-9 (1998).
Zhu, J., et al., “A Convergent Synthesis of 14-Membered F-O-G Ring Analogs of the Teicoplanin Binding Pocket via Intramolecular SNAr Reaction”,J. Org. Chem., (60), pp. 6389-6396 (1995).
Tokunaga, J., et al., “Reaction of Methylthioacetyl-peptides with Cyanogen Bromide.”Seikatsu Kageku. 12(1): 79-85 (1979).

Affiliated with

Also associated with

Rating

Methods and compounds for inhibiting β-amyloid peptide... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compounds for inhibiting β-amyloid peptide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compounds for inhibiting β-amyloid peptide... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3463724