Methods and compostions for enhancing transdermal drug delivery

Details Methods and compostions for enhancing transdermal drug delivery Methods and compostions for enhancing transdermal drug delivery

2009-05-14

2011-11-22

Epps-Smith, Janet L (Department: 1633)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S094100, C424S457000, C424S458000, C424S459000, C424S460000

Reexamination Certificate

active

08062663

ABSTRACT:
Methods and compositions for enhancing transdermal delivery of a bioactive agent. The method contains the step of applying to a skin tissue an effective amount of a composition comprising: (a) a drug vehicle; (b) a bioactive agent encapsulated within the drug vehicle; (c) a plurality of proteolytic enzyme molecules conjugated onto the surface of the drug vehicle; and (d) a pharmaceutically acceptable carrier, for a period of time effective to deliver the bioactive agent across the skin tissue at a desired dosage.

REFERENCES:
patent: 2004/0037809 (2004-02-01), Quay et al.
patent: 2007/0009583 (2007-01-01), Qvist
patent: 1957925 (2007-05-01), None
Kuhn et al. Nanoletters, vol. 6, No. 2, 2006, pp. 306-312.
E. Touitou., H. E. Jungingers.,N,. D. Weiner.,T. Naga., M. Mezei (1994) Liposome as Carriers for Topical and Trnasdermal Delivery Journal of Pharmaceutical Science 89(9): 1194-1203.
Y.C. Sim, Y.S. Nam, E.Shin, S.Kim, I.S. Chang, J. S. Rhee (2003) Proteolytic enzyme conjugated to SC-glucan as a enzymatic transdermal drug penetration enhancer Pharmazie 58:252-256.

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