Methods and compositions utilizing Rad51

Details Methods and compositions utilizing Rad51 Methods and compositions utilizing Rad51

1998-01-14

2000-07-18

Brusca, John S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 6, C12Q 100

Patent

active

060905395

ABSTRACT:
Compositions and methods are provided for identifying agents which bind to or modulate Rad51.

REFERENCES:
Haaf et al. Nuclear foci of mammalian rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc. Natl. Acad. Sci. USA vol. 92 pp. 2298-2302, 1995.
Hays et al. Complex formation in yeast double-strand break repair: Participation of rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. USA vol. 92 pp. 6925-6929, 1995.
Benson et al. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. EMBO J. vol. 13 pp. 5764-5771, 1994.
Chanet et al., "Semidominant Mutations in the Yeast Rad51 Protein and Their Relationships with the Srs2 Helicase," Molecular and Cellular Biology, 16(9):4782-4789 (Sep. 1996).
Sturzbecher et al., "p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction," EMBO Journal, 15(8):1992-2002 (1996).
Sharan et al., "Embryonic lethality and radiation hypersensitivy mediated by Rad51 in mice lacking Brca2," Nature, 386:804-810 (Apr. 1997).

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