Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Reexamination Certificate
2006-01-17
2006-01-17
Gitomer, Ralph (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
C435S004000, C435S011000, C514S001000, C530S354000
Reexamination Certificate
active
06987001
ABSTRACT:
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
REFERENCES:
patent: 5336496 (1994-08-01), Akimoto et al.
patent: 5443974 (1995-08-01), Hitz et al.
patent: 9108234.6 (1990-08-01), None
patent: WO 96/05861 (1996-02-01), None
patent: WO 99/63979 (1999-12-01), None
patent: WO 00/09754 (2000-02-01), None
Choi, et al., “The trans-10, cis-12 Isomer of Conjugated Linoleic Acid Downregulates Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes,” American Society for Nutritional Sciences, pp. 1920-1924 (2000).
Zoeller, et al., “The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatona7288C,” Elsevier Science Publishers B.V., pp. 380-388 (1985).
Bretillon, et al., “Effects of Conjugated Linoleic Acid Isomers on the Hepatic Microsomal Desaturation Activities in Vitro,” AOCS Press, vol. 24, No. 9, pp. 965-969 (1999).
Hovik, et al., “Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase,” Elsevier, pp. 251-256 (1997).
Khoo, et al., “Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo,” Macmillan Press Ltd., (1991).
Cao, et al., “Inhibition of fatty acid Δ6- and Δ5-desaturation by cyclopropene fatty acids in rat liver microsomes,” Elsevier Science Publishers, pp. 27-34 (1993).
Park, et al., “Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated acid and its derivatives,” Elsevier, pp. 285-292 (2000).
de Antueno, et al., “Relationship Between Mouse liver Δ9 Desaturase Activity,” American Oil Chemists' Society, vol. 28, No. 4 (1993).
Legrand, et al., “Inhibiting Δ9-Desaturase Activity Impairs Triacylglycerol Secretion in Cultured Chicken Hepatocytes” pp. 249-256 (1997).
Griinari, et al., “Conjugated Linoleic Acid is Synthesized Endogenously in Lactating Dairy Cows by Δ9-Desaturase,” American Society for Nutritional Sciences, pp. 2285-2291, (2000).
Jeffcoat, et al., “Studies on the Inhibition of the Desaturases by Cyclopropenoid Fatty Acids,” Lipids, vol. 12, No. 6.
Jeffcoat, et al., “Interrelationship between the Dietary Regulation of Fatty Acid Synthesis and the Fatty Acyl-CoA Desaturases,” Lipids, vol. 12, No. 6.
Kaestner, et al., “Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes,” Journal of Biological Chemistry, vol. 264, No. 25, pp. 14755-14761 (1991).
Ntambi, “Scdl is expressed in sebaceous glands and is disrupted in the asebia mouse,” Nature Genetics, vol. 23, (1999).
Ntambi, “Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol,” Journal of Lipid Research, vol. 40 (1999).
Legrand, et al., “Hepatic Δ9 desaturation and plasma VLDL level in genetically lean and fat chickens,” International Journal of Obesity, pp. 289-294 (1992).
Legrand, et al., “Stearoyl-CoA Desaturase Activity in Primary Culture of Chicken Hepatocytes. Influence of Insulin, Glucocorticoid, Fatty Acids and Cordycepin,” Int'l. J. Biochem, vol. 26, No. 6, pp. 777-785 (1994).
Lefevre, et al., “Hormonal Regulation of Stearoyl Coenzyme-A Desaturase 1 Activity and Gene Expression in Primary Cultures of Chicken Hepatocytes,” Archives of Biochemistry and Biophysics, vol. 368, No. 2, pp. 329-337 (Aug. 15, 1999).
Legrand, et al., Effect of Insulin on Triaclyglycerol Synthesis and Secretion by Chicken Hepatocyts in Primary Culture, Int'l. J. Biochem Cell Bio., vol. 28, No. 4, pp. 431-440 (1996).
Li, et al., “Partial Characterization of a cDNA for Human Stearoyl-CoA Desaturase and Changes in its mRNA Expression in Some Normal and Malignant Tissues,” Int'l. J. Cancer, pp. 348-352 (1994).Zh.
Zhang, et al., “Human Stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites,” Biochemical Society, pp. 255-264 (1999).
Waters et al., “Localization of a Negative Thyroid Hormone-Response Region in Hepatic Stearoyl-CoA Desaturase Gene 1”, Biochem. Biophys. Res. Comm., vol. 233, pp. 838-843, (1997).
Zhang et al., “Human Stearoyl-CoA Desaturase: Alternative Transcripts enerated from a Single Gene by Usage of Tandem Polyadenylation Sites”, vol. 340, pp. 255-264 (1999).
Database Biosis Online. Waters & Ntambi: “Polyunsaturated Fatty Acids Inhibit Hepatic Stearoyl-CoA Desaturase-1 Gene in Diabetic Mice”, vol. 31, No. Suppl., pp. S33-S36 (1996).
Kurebayashi S. et al., “Thiazolidinediones Downregulate Stearoyl-CoA Desaturase 1 Gene Expression in 3T3-L1 Adipocytes”, vol. 46, pp. 2115-2118, Dec. 1997.
Singh & Ntambi, “Nuclear Factor 1 is Essential Fir the Expression of Stearoyl-CoA Desaturase 1 Gene During Preadipocyte Differentiation”, Biochim. Biophys. Acta, vol. 1398, 1998, pp. 148-156.
Sessler et al., “Regulation of Stearoyl-CoA Desaturase 1 mRNA Stability by Polyunsaturated Fatty Acids in 3T3-L1 Adipocytes”, J. Biol. Chem., vol. 271, No. 47, pp. 29854-29858 (Nov. 22, 1996).
NTAMBI: “Regulation of Stearoyl-CoA Desaturate by Polyunsaturated Fatty Acids and Cholesterol”, vol. 40, pp. 1549-1558 (1999).
Park et al., “Lipid Level and Type Alter Stearoyl CoA Desaturase mRNA Abundance Differently in Mice with Distinct Susceptibilities to Diet-Influenced Diseases”, vol. 127, pp. 566-573.
Clarke et al., Prog. Lipid Res., 32, 139-149 (1993).
Kim et al., J. Lipid Res., 41, 1310-1316 (2000).
Skrede et al., Biochim. Biophys. Acta, 1344, 115-131 (1997).
Li et al., Int.J. Cancer, 57, 348-352 (1994).
Miyazaki et al., J. Biol. Chem., 275, 30132-30138 (2000).
Paisley et al., J. Nutr., 126, 2730-2737 (1996).
Waters et al., J. Biol. Chem., 269, 27773-27777 (1994).
Attie Alan D.
Brownlie Alison J.
Gray-Keller Mark P.
Hayden Michael R.
Miyazaki Makoto
Gitomer Ralph
Grant Alan J.
Olstein Elliot M.
Srivastava Kailash C.
University of British Columbia
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