Methods and compositions using butyrate esters of threitol

Details Methods and compositions using butyrate esters of threitol Methods and compositions using butyrate esters of threitol

1998-01-29

1999-08-31

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514547, 514588, A61K 3170, A61K 31225, A61K 3117

Patent

active

059454075

ABSTRACT:
The present invention relates to the use of butyrate esters of threitol, alone or in combination with other agents, in pharmaceutical compositions and methods for increasing fetal hemoglobin and gamma globin in a patient. These methods are particularly useful in treating .beta.-hemoglobinopathies, such as sickle cell syndromes and .beta.-thalassemia syndromes. Compositions comprising butyrate esters of threitol, alone or in combination antiproliferative and differentiating agents are also useful in methods for inducing cell differentiation in malignant cells. These methods are useful in treating cancer, particularly the tetrabutyrate ester.

REFERENCES:
patent: 5569675 (1996-10-01), Rephaeli
patent: 5763488 (1998-06-01), Bemis et al.
Charles Chany and Italina Cerutti, "Antitumor Effect of Arginine Butyrate in Conjunction with Corynebacterium Parvum and Interferon," Int. J. Cancer, vol. 30, pp. 489-493 (1982).
Zi-Xing Chen and Theodore R. Breitman, "Tributyrin: A Prodrug of Butyric Acid for Potential Clinical Application in Differentiation Therapy," Cancer Research, vol. 54, pp. 3494-3499 (1994).
Anne F. Collins et al., "Oral Sodium Phenylbutyrate Therapy in Homozygous .beta.-Thalassemia: A Clinical Trial," Blood, vol. 85, No. 1, pp. 43-49 (1995).
Angela Hague et al., "Apoptosis in Colorectal Tumour Cells: Induction by the Short Chain Fatty Acids Butyrate, Propionate and Acetate and by the Bile Salt Deoxycholate," Int. J. Cancer, vol. 60, pp. 400-406 (1995).
Antonius A. Miller et al., "Clinical Pharmacology of Sodium Butyrate in Patients with Acute Leukemia," Eur. J. Cancer Clin. Oncol., vol. 23, No. 9, pp. 1283-1287 (1987).
Harold L. Newmark et al, "Butyrate as a Differentiating Agent: Pharmacokinetics, Analogues and Current Status," Cancer Letters, vol. 78, pp. 1-5 (1994).
Harold L. Newmark and Charles W. Young, "Butyrate and Phenylacetate as Differentiating Agents: Practical Problems and Opportunities," J. Cell. Biochem., Supplement 22, pp. 247-253 (1995).
Abraham Novogrodsky et al., "Effect of Polar Organic Compounds on Leukemic Cells: Butyrate-Induced Partial Remission of Acute Myelogenous Leukemia in a Child," Cancer, vol. 51, No. 1, pp. 9-14 (1983).
Abraham Nudelman et al., "Novel Anticancer Prodrugs of Butyric Acid," J. Med. Chem., vol. 35, pp. 694-704 (1992).
Michiro Otaka et al., "Antibody-Mediated Targeting of Differentiation Inducers to Tumor Cells: Inhibition of Colonic Cancer Cell Growth In Vitro and In Vivo, A Preliminary Note," Biochem. Biophy. Res. Comm., vol. 158, No. 1, pp. 202-208 (1989).
Philippe Pouillart et al, "Butyric Monosaccharide Ester-Induced Cell Differentiation And Anti-Tumor Activity In Mice. Importance Of Their Prolonged Biological Effect For Clinical Applications In Cancer Therapy," Int. J. Cancer, vol. 49, pp. 89-95 (1991).
Philippe Pouillart et al., "Pharmacokinetic Studies of N-Butyric Acid Mono-and Polyesters Derived from Monosaccharides," J. Pharm. Sci., vol. 81, No. 3, pp. 241-244 (1992).
K. N. Prasad, "Butyric Acid: A Small Fatty Acid with Diverse Biological Functions," Life Sci., vol. 27, pp. 1351-1358 (1980).
O. C. Velazquez et al., "Butyrate and the Colonocyte: Implications for Neoplasia," Dig. Dis. Sci., vol. 41, pp. 727-739 (1996).

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