Methods and compositions useful in the recognition, binding and

Details Methods and compositions useful in the recognition, binding and Methods and compositions useful in the recognition, binding and

1995-06-07

1998-06-30

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 530350, 536 231, C12P 2102, C12N 1510, C12N 1511, C07K 1400

Patent

active

057732469

ABSTRACT:
Methods and compounds are described that allow partitioning of messenger RNAs encoding runctionally related proteins, in particular those involved in cellular growth and differentiation, based upon binding to target sequences in the untranslated portions of the RNAS. The preparation of mRNA-subset libraries containing genes encoding such growth regulatory factors is described together with novel gene sequences derived useing these mRNA partitioning methods. These methods of mRNA partitioning allow access to growth regulatory factors unique to a given cell, tissue or tumor and provide a method of fingerprinting such factors.

REFERENCES:
Chu et al. Identification of in vivo target RNA sequences bound by thymidylate synthase. Nucleic Acids Research vol. 24 pp. 3222-3228, 1996.

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