Methods and compositions useful in the recognition, binding and

Details Methods and compositions useful in the recognition, binding and Methods and compositions useful in the recognition, binding and

1993-09-15

1996-06-11

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351721, 935 19, 935 22, 935 77, 935 80, 530350, 530300, C12N 1500, C07K 1400

Patent

active

055254950

ABSTRACT:
Methods and compounds are described that allow partitioning of messenger RNAs encoding runctionally related proteins, in particular those involved in cellular growth and differentiation, based upon binding to target sequences in the untranslated portions of the RNAs. The preparation of mRNA-subset libraries containing genes encoding such growth regulatory factors is described together with novel gene sequences derived useing these mRNA partitioning methods. These methods of mRNA partitioning allow access to growth regulatory factors unique to a given cell, tissue or tumor and provide a method of fingerprinting such factors.

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Tsai et al. VAR 19(18):4931, 1991.
Starr et al. Cell 46:659, 1986.
Tuerh et al. Science 249:505, 1990.
Levine et al. Mol Cell Biol 13(6):3494, 1993.

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