Methods and compositions to lower plasma cholesterol levels

Details Methods and compositions to lower plasma cholesterol levels Methods and compositions to lower plasma cholesterol levels

2005-05-03

2005-05-03

Chin, Chris (Department: 1641)

Chemistry: analytical and immunological testing

Lipids, triglycerides, cholesterol, or lipoproteins

C435S007100, C435S007720, C435S007920, C435S007940, C436S501000, C436S515000, C436S523000, C436S536000, C436S537000, C436S546000, C436S518000, C436S524000, C436S528000, C436S055000, C436S071000, C436S164000, C436S172000, C436S805000, C436S815000

Reexamination Certificate

active

06887712

ABSTRACT:
A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol. The method provided includes assessing the ability of the compound to form a complex with the lipoprotein, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to an LDL receptor.

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